IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta
Mao, Yuanjie1,2; Su, Jialin1,3,4; Lei, Lei5; Meng, Lei1; Qi, Yongfen6; Huo, Yong1; Tang, Chaoshu6
关键词angiotensin II regulators of G protein signaling 2 vascular remodeling vascular smooth muscle cell
刊名JOURNAL OF CARDIOVASCULAR MEDICINE
2014-07-01
DOI10.2459/JCM.0b013e3283629c30
15期:7页:572-578
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]SMOOTH-MUSCLE-CELLS ; ANGIOTENSIN-II ; HYPERTENSIVE PATIENTS ; GENERAL-POPULATION ; BLOOD-PRESSURE ; RGS2 ; EXPRESSION ; G-PROTEIN-SIGNALING-2 ; POLYMORPHISMS ; HYPERTROPHY
英文摘要

BackgroundThe activation of Gq-protein-coupled receptors induces proliferation of vascular smooth muscle cells (VSMCs) proliferation and is involved in vascular remodeling. The regulator of G protein signaling 2 (RGS2), which accelerates the termination of Gq protein signaling, may play a role in vascular remodeling. However, this role remains unclear.MethodsAortic balloon injury or sham operation was produced in male Wistar rats. Histological examination and gene expression analysis were performed after surgery. In cultured VSMCs after modulation of RGS2 expression, cell proliferation was also evaluated.ResultsAt day 3 after injury, RGS2 transcription was reduced by 52.8% (P<0.05 vs. sham group) with vascular remodeling. In cultured VSMCs stimulated by endothelin-1, phenylephrine or angiotensin II, the proliferation of RGS2 overexpressed cells was significantly inhibited; the proliferation of RGS2 downregulated cells was significantly promoted, compared with that of RGS2 normal cells. Moreover, after incubation with angiotensin II of high concentration (>10mol/l) or long term (>8h), the RGS2 expression was clearly downregulated in cultured VSMCs. Administration of an angiotensin receptor blocker, valsartan (20mg/kg per day) starting from 1 week preballoon injury to 3 days after injury, restored aortic RGS2 transcription and improved vascular remodeling.ConclusionThese results suggested that the inhibiting effect of RGS2 on VSMC proliferation is downregulated in vascular remodeling of injured rat aorta, and this effect is likely to be mediated by angiotensin II signaling.

语种英语
WOS记录号WOS:000337701100007
项目编号NSFC30600230 ; 331
资助机构National Nature Science Foundation of China ; Chinese Doctoral Foundation
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63970
专题北京大学第一临床医学院_心血管内科
北京大学临床肿瘤学院_肝胆胰外二科
作者单位1.Brown Univ, Alpert Med Sch, Providence, RI 02912 USA
2.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China
3.Natl Cerebral & Cardiovasc Ctr, Dept Biochem, Osaka, Japan
4.Brown Univ, Rhode Isl Hosp, Div Cardiol, Cardiovasc Res Ctr, Providence, RI 02903 USA
5.Peking Univ, Dept Endocrinol, Beijing Aerosp Ctr Hosp, Beijing 100034, Peoples R China
6.Peking Univ, Dept Physiol, Sch Basic Med Sci, Beijing 100034, Peoples R China
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Mao, Yuanjie,Su, Jialin,Lei, Lei,et al. Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta[J]. JOURNAL OF CARDIOVASCULAR MEDICINE,2014,15(7):572-578.
APA Mao, Yuanjie.,Su, Jialin.,Lei, Lei.,Meng, Lei.,Qi, Yongfen.,...&Tang, Chaoshu.(2014).Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta.JOURNAL OF CARDIOVASCULAR MEDICINE,15(7),572-578.
MLA Mao, Yuanjie,et al."Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta".JOURNAL OF CARDIOVASCULAR MEDICINE 15.7(2014):572-578.
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