北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats
作者: Han, Ying; Yi, Wenxia; Qin, Jiong; Zhao, Yang; Zhang, Jing; Chang, Xingzhi
关键词: Sulfur dioxide ; Aspartate aminotransferase ; Febrile seizures ; Brain damage
刊名: NEUROSCIENCE LETTERS
发表日期: 2014-03-20
DOI: 10.1016/j.neulet.2013.12.042
卷: 563, 页:149-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: HYDROGEN-SULFIDE ; NITRIC-OXIDE ; OXIDATIVE STRESS ; INJURY ; RECEPTOR ; MICE
英文摘要:

Sulfur dioxide (SO2) regulates many physiological processes. Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that endogenous SO2 in the plasma and hippocampus was increased, accompanied by upregulation of aspartate amino-transferase 1 (AAT1) and AAT2, and neuronal apoptosis and mossy fiber sprouting (MFS) in the hippocampus. Preconditioning with low concentration of SO2 (1-10 mu mol/kg) alleviated the neuronal damage, and attenuated neuronal apoptosis and MFS, whereas preconditioning with high concentration of SO2 (100 mu mol/kg) or inhibition of AAT aggravated the neuronal damage, and promoted neuronal apoptosis and MFS in hippocampus of rats with recurrent FS. These data indicate that endogenous SO2 is involved in the development of FS and related brain damage. Preconditioning with low concentration of SO2 may protect neurons from toxicity caused by FS. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 81200998 ; 7092105 ; 7112131 ; 2010-12 ; 2012BAI03B02
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Ministry of Public Health ; National Key Technology RD Program
WOS记录号: WOS:000334005900031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63991
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Han, Ying,Yi, Wenxia,Qin, Jiong,et al. Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats[J]. NEUROSCIENCE LETTERS,2014,563:149-154.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, Ying]'s Articles
[Yi, Wenxia]'s Articles
[Qin, Jiong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, Ying]‘s Articles
[Yi, Wenxia]‘s Articles
[Qin, Jiong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace