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Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats
Han, Ying; Yi, Wenxia; Qin, Jiong; Zhao, Yang; Zhang, Jing; Chang, Xingzhi
关键词Sulfur dioxide Aspartate aminotransferase Febrile seizures Brain damage
刊名NEUROSCIENCE LETTERS
2014-03-20
DOI10.1016/j.neulet.2013.12.042
563页:149-154
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]HYDROGEN-SULFIDE ; NITRIC-OXIDE ; OXIDATIVE STRESS ; INJURY ; RECEPTOR ; MICE
英文摘要

Sulfur dioxide (SO2) regulates many physiological processes. Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that endogenous SO2 in the plasma and hippocampus was increased, accompanied by upregulation of aspartate amino-transferase 1 (AAT1) and AAT2, and neuronal apoptosis and mossy fiber sprouting (MFS) in the hippocampus. Preconditioning with low concentration of SO2 (1-10 mu mol/kg) alleviated the neuronal damage, and attenuated neuronal apoptosis and MFS, whereas preconditioning with high concentration of SO2 (100 mu mol/kg) or inhibition of AAT aggravated the neuronal damage, and promoted neuronal apoptosis and MFS in hippocampus of rats with recurrent FS. These data indicate that endogenous SO2 is involved in the development of FS and related brain damage. Preconditioning with low concentration of SO2 may protect neurons from toxicity caused by FS. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000334005900031
项目编号81200998 ; 7092105 ; 7112131 ; 2010-12 ; 2012BAI03B02
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Ministry of Public Health ; National Key Technology RD Program
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63991
专题北京大学第二临床医学院_儿科
北京大学第一临床医学院_儿科
作者单位Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
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Han, Ying,Yi, Wenxia,Qin, Jiong,et al. Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats[J]. NEUROSCIENCE LETTERS,2014,563:149-154.
APA Han, Ying,Yi, Wenxia,Qin, Jiong,Zhao, Yang,Zhang, Jing,&Chang, Xingzhi.(2014).Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats.NEUROSCIENCE LETTERS,563,149-154.
MLA Han, Ying,et al."Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats".NEUROSCIENCE LETTERS 563(2014):149-154.
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