|The Association between Changes in Urinary Albumin-to-Creatinine Ratio and Risk of Abnormal Ankle-Brachial Index in a Community-Based Chinese Population|
|Niu, Fukun1,2,3,4,5; Zhang, Luxia1,2,3,4; Wang, Xingyu6; Liu, Lisheng6; Wang, Haiyan1,2,3,4|
|关键词||Albumin-to-creatinine ratio Ankle-brachial index Epidemiology|
|刊名||JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS|
|WOS标题词||Science & Technology|
|类目[WOS]||Peripheral Vascular Disease|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||PERIPHERAL ARTERIAL-DISEASE ; CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; NUTRITION EXAMINATION SURVEY ; CARDIOVASCULAR HEALTH ; NATIONAL-HEALTH ; ATHEROSCLEROSIS ; MORTALITY ; MICROALBUMINURIA ; PREVALENCE|
Aims: To investigate the prospective association between changes in the urinary albumin-creatinine ratio (ACR) and abnormal ankle-brachial index (ABI) in a community-based Chinese population.
Methods: This prospective cohort study included 799 residents aged 58.3 +/- 9.2 years and without a history of cardiovascular disease from an urban district of Beijing, China. Urinary ACR was measured at baseline, and at 4 and 6 years of follow-up. The 75th percentile of the baseline urinary ACR (5.82 mg/g) was used to define "high" ACR. The changes in urinary ACR were categorized as consistently low urinary ACR, intermittent high urinary ACR, and consistently high urinary ACR. ABI was measured at 6 years of follow-up. Multinomial logistic regression was used to evaluate the associations of changes in urinary ACR categories with the ABI categories.
Results: During 6 years of follow-up, 16.1% of participants (n = 128) had low ABI and 13.9% of participants (n = 111) had high ABI. After adjusting for potential confounders including baseline albuminuria, individuals who had consistently high urinary ACR or intermittent high urinary ACR had a significantly higher risk for low ABI than individuals who had consistently low urinary ACR, with odds ratios (OR) of 2.75 (95% CI, 1.37-5.52) and 2.06 (95% CI, 1.18-3.57), respectively. No independent association was observed between changes in urinary ACR and high ABI among participants.
Conclusion: Changes in urinary ACR below the definition for albuminuria predict low ABI among this community-based population without a history of cardiovascular disease.
|项目编号||BMU2009131 ; 2009-Z-SQ01|
|资助机构||Program for New Century Excellent Talents in Universities from the Ministry of Education of the People&prime ; s Republic of China ; International Society of Nephrology Research Committee ; Beijing Municipal Health Bureau ; China Health and Medical Development Foundation|
|作者单位||1.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China|
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
5.Zhengzhou Univ, Affiliated Hosp 1, Dept Nephrol, Zhengzhou, Henan, Peoples R China
6.Beijing Hypertens League Inst, Beijing, Peoples R China
|Niu, Fukun,Zhang, Luxia,Wang, Xingyu,et al. The Association between Changes in Urinary Albumin-to-Creatinine Ratio and Risk of Abnormal Ankle-Brachial Index in a Community-Based Chinese Population[J]. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,2012,19(10):912-917.|
|APA||Niu, Fukun,Zhang, Luxia,Wang, Xingyu,Liu, Lisheng,&Wang, Haiyan.(2012).The Association between Changes in Urinary Albumin-to-Creatinine Ratio and Risk of Abnormal Ankle-Brachial Index in a Community-Based Chinese Population.JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,19(10),912-917.|
|MLA||Niu, Fukun,et al."The Association between Changes in Urinary Albumin-to-Creatinine Ratio and Risk of Abnormal Ankle-Brachial Index in a Community-Based Chinese Population".JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 19.10(2012):912-917.|