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学科主题: 临床医学
题名:
Meta-analysis on autologous stem cell transplantation in the treatment of limb ischemic
作者: Sun, Xiuqin1; Ying, Jilin2; Wang, Yunan3; Li, Wei5; Wu, Yaojiang4; Yao, Baoting3; Liu, Ying3; Gao, Hongkai6; Zhang, Xiaomei7
关键词: Stem cell ; limb ischemic ; meta-analysis
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:6, 页:8740-8748
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: PERIPHERAL ARTERIAL-DISEASE ; DOUBLE-BLIND ; MYELOMA PATIENTS ; THERAPY ; TRIAL ; ANGIOGENESIS ; NEOVASCULARIZATION ; MULTICENTER ; HINDLIMB ; PLACEBO
英文摘要:

Aim: Meta-analysis on the effectiveness of the autologous stem cell transplantation in curing limb ischemic. Method: Consulting papers relate to the autologous stem cell transplantation in curing limb ischemic in PubMed, CNKI, Wan-fang Data and VIP. Based on include and exclude standards, we arrange at least 2 evaluators sifting these papers separately, doing Quality evaluation and information extraction and then cross checking. Negotiate through a third party if any disagreement comes out. Review Manager 4.2 is used in Meta-analysis. Result: Involved 7 papers, all in English version. Patients involved all diagnosed as critical limb ischemia (CLI). Results show that no adverse reaction occurred during this study. Amputation rate in patients with stem cell group treatment is lower than control group (P < 0.05). And no notable difference in improving ABI (P > 0.05). Conclusions: Applying autologous stem cell transplantation in curing limb ischemic does not have obviously effectiveness in the improvement of ABI of the limb ischemic patients. But it can dramatically reduce the rate of amputation. So autologous stem cell transplantation is a good and safe choice for patients have no choice but amputation.

语种: 英语
WOS记录号: WOS:000359295600043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63996
Appears in Collections:北京大学国际医院_期刊论文

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作者单位: 1.Capital Med Univ, Dept Endocrinol & Metab, Anzhen Hosp Beijing, Beijing, Peoples R China
2.Puren Hosp Beijing, Dept Orthoped, Beijing, Peoples R China
3.First Hosp Dandong, Dept Endocrinol, Liaoning, Peoples R China
4.First Hosp Dandong, Dept Gen Surg, Liaoning, Peoples R China
5.Second Mil Med Univ, Changhai Hosp, Dept Gen Surg, Shanghai, Peoples R China
6.Gen Hosp Armed Police, Dept Gen Surg, Beijing, Peoples R China
7.Peking Univ, Int Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Xiuqin,Ying, Jilin,Wang, Yunan,et al. Meta-analysis on autologous stem cell transplantation in the treatment of limb ischemic[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(6):8740-8748.
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