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The Impact of Graft Composition on Clinical Outcomes in Pediatric Patients Undergoing Unmanipulated HLA-Mismatched/Haploidentical Hematopoietic Stem Cell Transplantation
Liu, Dai-Hong; Zhao, Xiao-Su; Chang, Ying-Jun; Liu, Yan-Kai; Xu, Lan-Ping; Chen, Huan; Han, Wei; Chen, Yu-Hong; Wang, Yu; Huang, Xiao-Jun
关键词CD3/CD14 ratio children graft composition haploidentical hematopoietic stem cell transplantation
刊名PEDIATRIC BLOOD & CANCER
2011-07-01
DOI10.1002/pbc.23107
57期:1页:135-141
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology ; Pediatrics
研究领域[WOS]Oncology ; Hematology ; Pediatrics
关键词[WOS]COLONY-STIMULATING FACTOR ; VERSUS-HOST-DISEASE ; IDENTICAL SIBLING TRANSPLANTATION ; PERIPHERAL-BLOOD ; BONE-MARROW ; ALLOGENEIC TRANSPLANTATION ; HAPLOIDENTICAL BLOOD ; HEMATOLOGICAL MALIGNANCIES ; ANTITHYMOCYTE GLOBULIN ; PLATELET ENGRAFTMENT
英文摘要

Objective. In pediatric patients, the association of graft composition with clinical outcomes after unmanipulated haploidentical hematopoietic stem cell transplantation has not been well defined. Therefore, the impact of graft composition on transplant outcomes was evaluated. Methods. We examined the absolute numbers and relative proportions of CD3+, CD4+, CD8+, CD14+, and CD34+ cells contained in allografts of 103 children who underwent unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T cell depletion. Results. Multivariate analysis showed that a high CD34+ cell dose in G-CSF-primed bone marrow and peripheral blood grafts (G-PB) was related to accelerated platelet engraftment (P = 0.004). A higher CD3/CD14 ratio in G-PB (>= 1.30) was associated with grade II-IV acute graft-versus-host disease (GVHD) (HR = 3.552; 95% CI 1.015-12.428, P = 0.047). In addition, only a heavier donor weight (HR = 5.837; 95% CI 1.841-18.513, P = 0.003) and a higher ratio of CD3/CD14 in the total graft (HR = 9.752; 95% CI 1.834-51.865, P = 0.008) were associated with worse overall survival. No aspect of graft composition affected neutrophil engraftment or disease relapse, though occurrence of chronic GVHD and a higher CD3/CD14 ratio in G-PB and total graft may reflect a lower incidence of relapse without statistical significance. Conclusions. The dose of CD34+ cells and the CD3/CD14 ratio in allografts seem to have prognostic value for engraftment and clinical outcomes in pediatric patients undergoing unmanipulated haploidentical hematopoietic stem cell transplantation. A lower CD3/CD14 ratio in allografts demonstrated a survival benefit. Pediatr Blood Cancer 2011;57: 135-141. (C) 2011 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000290452400022
项目编号30725038 ; IRT0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64000
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
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Liu, Dai-Hong,Zhao, Xiao-Su,Chang, Ying-Jun,et al. The Impact of Graft Composition on Clinical Outcomes in Pediatric Patients Undergoing Unmanipulated HLA-Mismatched/Haploidentical Hematopoietic Stem Cell Transplantation[J]. PEDIATRIC BLOOD & CANCER,2011,57(1):135-141.
APA Liu, Dai-Hong.,Zhao, Xiao-Su.,Chang, Ying-Jun.,Liu, Yan-Kai.,Xu, Lan-Ping.,...&Huang, Xiao-Jun.(2011).The Impact of Graft Composition on Clinical Outcomes in Pediatric Patients Undergoing Unmanipulated HLA-Mismatched/Haploidentical Hematopoietic Stem Cell Transplantation.PEDIATRIC BLOOD & CANCER,57(1),135-141.
MLA Liu, Dai-Hong,et al."The Impact of Graft Composition on Clinical Outcomes in Pediatric Patients Undergoing Unmanipulated HLA-Mismatched/Haploidentical Hematopoietic Stem Cell Transplantation".PEDIATRIC BLOOD & CANCER 57.1(2011):135-141.
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