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学科主题: 临床医学
题名:
The Impact of Graft Composition on Clinical Outcomes in Pediatric Patients Undergoing Unmanipulated HLA-Mismatched/Haploidentical Hematopoietic Stem Cell Transplantation
作者: Liu, Dai-Hong; Zhao, Xiao-Su; Chang, Ying-Jun; Liu, Yan-Kai; Xu, Lan-Ping; Chen, Huan; Han, Wei; Chen, Yu-Hong; Wang, Yu; Huang, Xiao-Jun
关键词: CD3/CD14 ratio ; children ; graft composition ; haploidentical ; hematopoietic stem cell transplantation
刊名: PEDIATRIC BLOOD & CANCER
发表日期: 2011-07-01
DOI: 10.1002/pbc.23107
卷: 57, 期:1, 页:135-141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology ; Pediatrics
研究领域[WOS]: Oncology ; Hematology ; Pediatrics
关键词[WOS]: COLONY-STIMULATING FACTOR ; VERSUS-HOST-DISEASE ; IDENTICAL SIBLING TRANSPLANTATION ; PERIPHERAL-BLOOD ; BONE-MARROW ; ALLOGENEIC TRANSPLANTATION ; HAPLOIDENTICAL BLOOD ; HEMATOLOGICAL MALIGNANCIES ; ANTITHYMOCYTE GLOBULIN ; PLATELET ENGRAFTMENT
英文摘要:

Objective. In pediatric patients, the association of graft composition with clinical outcomes after unmanipulated haploidentical hematopoietic stem cell transplantation has not been well defined. Therefore, the impact of graft composition on transplant outcomes was evaluated. Methods. We examined the absolute numbers and relative proportions of CD3+, CD4+, CD8+, CD14+, and CD34+ cells contained in allografts of 103 children who underwent unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T cell depletion. Results. Multivariate analysis showed that a high CD34+ cell dose in G-CSF-primed bone marrow and peripheral blood grafts (G-PB) was related to accelerated platelet engraftment (P = 0.004). A higher CD3/CD14 ratio in G-PB (>= 1.30) was associated with grade II-IV acute graft-versus-host disease (GVHD) (HR = 3.552; 95% CI 1.015-12.428, P = 0.047). In addition, only a heavier donor weight (HR = 5.837; 95% CI 1.841-18.513, P = 0.003) and a higher ratio of CD3/CD14 in the total graft (HR = 9.752; 95% CI 1.834-51.865, P = 0.008) were associated with worse overall survival. No aspect of graft composition affected neutrophil engraftment or disease relapse, though occurrence of chronic GVHD and a higher CD3/CD14 ratio in G-PB and total graft may reflect a lower incidence of relapse without statistical significance. Conclusions. The dose of CD34+ cells and the CD3/CD14 ratio in allografts seem to have prognostic value for engraftment and clinical outcomes in pediatric patients undergoing unmanipulated haploidentical hematopoietic stem cell transplantation. A lower CD3/CD14 ratio in allografts demonstrated a survival benefit. Pediatr Blood Cancer 2011;57: 135-141. (C) 2011 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 30725038 ; IRT0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University
WOS记录号: WOS:000290452400022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64000
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Dai-Hong,Zhao, Xiao-Su,Chang, Ying-Jun,et al. The Impact of Graft Composition on Clinical Outcomes in Pediatric Patients Undergoing Unmanipulated HLA-Mismatched/Haploidentical Hematopoietic Stem Cell Transplantation[J]. PEDIATRIC BLOOD & CANCER,2011,57(1):135-141.
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