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学科主题临床医学
Correlation between coagulation function, tumor stage and metastasis in patients with renal cell carcinoma: a retrospective study
Xiao Bo; Ma Lu-lin; Zhang Shu-dong; Xiao Chun-lei; Lu Jian; Hong Kai; Liao Hong-yi
关键词renal cell carcinoma fibrinogen metastasis hypeifibrinogenemia
刊名CHINESE MEDICAL JOURNAL
2011-04-20
DOI10.3760/cma.j.issn.0366-6999.2011.08.015
124期:8页:1205-1208
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; PLASMA-FIBRINOGEN ; LYMPHATIC METASTASIS ; GASTRIC-CANCER ; ANGIOGENESIS ; HYPERFIBRINOGENEMIA ; PROGRESSION ; EXPRESSION ; PREDICTOR ; PATHWAY
英文摘要

Background The coagulation function in carcinoma patients is abnormal, but in renal cell carcinoma the extent and relationships of coagulation function remain unclear. This study retrospectively investigated the relationships between coagulation function, clinical stage and metastasis in patients with renal cell carcinoma.

Methods A total of 350 consecutive patients admitted to our Urology Department from 2004 to 2010 were diagnosed with renal cell carcinoma by histolopathologic examination and were included in this study. A total of 231 cases of renal benign tumors were considered as the control group. Fibrinogen, prothrombin time, activated partial thromboplastin time and international normalized ratio were evaluated in all subjects. Tumor size, clinical stage, lymph node metastasis, and distant metastasis were evaluated using radiologic imaging, intraoperative findings, and histological studies.

Results The preoperative plasma fibrinogen levels of patients with renal cell carcinoma ((383.9 +/- 146.7) mg/dl) were significantly higher than those of the control group ((316.7 +/- 62.0) mg/dl) (P <0.01). We divided the renal cell carcinoma group into stages Ia, Ib, II, III, and IV. The fibrinogen values were (315.6 +/- 64.6) mg/dl, (358.3 +/- 91.1) mg/dl, (465.6 +/- 164.7) mg/dl, (500.0 +/- 202.1) mg/dl, and (585.8 +/- 179.7) mg/dl, respectively. There were no significant differences in fibrinogen values between stage la and control groups. However, results of other stages showed significant differences when compared to control group values (P <0.01). Using the cutoff value of 440 mg/dl, which defines hyperfibrinogenemia, plasma fibrinogen levels had a positive predictive value of 39.8% and a negative predictive value of 93.3% for predicting distant metastasis, with a sensitivity of 64.7% and specificity of 83.3%.

Conclusions Preoperative plasma fibrinogen levels are elevated in patients with renal cell carcinoma with distant metastasis or lymph node metastasis. Potential metastasis is more likely if the tumor size larger than 4 cm. Increased preoperative plasma fibrinogen levels, especially hyperfibrinogenemia, may be an indicator of metastasis. Chin Med J 2011;124(8):1205-1208

语种英语
WOS记录号WOS:000290289800015
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64005
专题北京大学第三临床医学院_泌尿外科
作者单位Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xiao Bo,Ma Lu-lin,Zhang Shu-dong,et al. Correlation between coagulation function, tumor stage and metastasis in patients with renal cell carcinoma: a retrospective study[J]. CHINESE MEDICAL JOURNAL,2011,124(8):1205-1208.
APA Xiao Bo.,Ma Lu-lin.,Zhang Shu-dong.,Xiao Chun-lei.,Lu Jian.,...&Liao Hong-yi.(2011).Correlation between coagulation function, tumor stage and metastasis in patients with renal cell carcinoma: a retrospective study.CHINESE MEDICAL JOURNAL,124(8),1205-1208.
MLA Xiao Bo,et al."Correlation between coagulation function, tumor stage and metastasis in patients with renal cell carcinoma: a retrospective study".CHINESE MEDICAL JOURNAL 124.8(2011):1205-1208.
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