IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科
学科主题口腔医学
Primary oncocytic carcinoma of the salivary glands: A clinicopathologic and immunohistochemical study of 12 cases
Zhou, Chuan-Xiang1; Shi, Dian-Yin2; Ma, Da-quan2; Zhang, Jian-guo2; Yu, Guang-Yan2; Gao, Yan1
关键词Oncocytic carcinoma Salivary gland Clinicopathologic Immunohistochemistry Salivary tumour
刊名ORAL ONCOLOGY
2010-10-01
DOI10.1016/j.oraloncology.2010.07.014
46期:10页:773-778
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]PAROTID-GLAND ; SUBMANDIBULAR-GLAND ; TUMORS
英文摘要

Oncocytic carcinoma (OC) of salivary gland origin is an extremely rare proliferation of malignant oncocytes with adenocarcinomatous architectural phenotypes, including infiltrative qualities. To help clarify the clinicopathologic and prognostic features of this tumor group, herein, we report 12 OC cases arising from the salivary glands, together with follow-up data and immunohistochemical observations. There were 10 males and 2 females with an age range of 41 to 86 years ( median age: 61.3 years). Most occurred in the parotid gland (10/12) with one in the palate and one in the retromolar gland. The tumors were unencapsulated and often invaded into the nearby gland, lymphatic tissues and nerves. The neoplastic cells had eosinophilic granular cytoplasm and round vesicular nuclei with prominent red nucleoli. Ultrastructural study, PTAH, and immunohistochemistry staining confirmed the presence of numerous mitochondria in the cytoplasm of oncocytes. Cellular atypia and pleomorphism varied in the current series. Double nuclei and mitoses were observed in some cases, while one case that showed mild cellular pleomorphism but had local invasion following local recurrence was also identified as an OC. Of the 11 cases with follow-up information, 7 cases had local recurrence. Regional or distant metastases were found in 6 and 4 cases, respectively. Five-year disease-specific survivals were 54.9%. In summary, OC of salivary gland origin is a high-grade tumor, often with local recurrence, regional or distant metastasis, diagnosis of which based on a combination of clinical and histopathological features. Immunohistochemistry for mitochondria is considered as a practical and helpful adjuvant diagnosis. Complete surgical excision is the treatment of choice while the role of radiotherapy or chemotherapy is controversial, and careful follow-up is necessary. (C) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000282281600012
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64008
专题北京大学口腔医学院_口腔病理科
北京大学口腔医学院_外科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Chuan-Xiang,Shi, Dian-Yin,Ma, Da-quan,et al. Primary oncocytic carcinoma of the salivary glands: A clinicopathologic and immunohistochemical study of 12 cases[J]. ORAL ONCOLOGY,2010,46(10):773-778.
APA Zhou, Chuan-Xiang,Shi, Dian-Yin,Ma, Da-quan,Zhang, Jian-guo,Yu, Guang-Yan,&Gao, Yan.(2010).Primary oncocytic carcinoma of the salivary glands: A clinicopathologic and immunohistochemical study of 12 cases.ORAL ONCOLOGY,46(10),773-778.
MLA Zhou, Chuan-Xiang,et al."Primary oncocytic carcinoma of the salivary glands: A clinicopathologic and immunohistochemical study of 12 cases".ORAL ONCOLOGY 46.10(2010):773-778.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhou, Chuan-Xiang]的文章
[Shi, Dian-Yin]的文章
[Ma, Da-quan]的文章
百度学术
百度学术中相似的文章
[Zhou, Chuan-Xiang]的文章
[Shi, Dian-Yin]的文章
[Ma, Da-quan]的文章
必应学术
必应学术中相似的文章
[Zhou, Chuan-Xiang]的文章
[Shi, Dian-Yin]的文章
[Ma, Da-quan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。