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学科主题: 临床医学
题名:
Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis
作者: Huo, Y.1; Qin, X.2; Wang, J.3; Sun, N.4; Zeng, Q.5; Xu, X.6; Liu, L.7,8; Xu, X.2; Wang, X.9
刊名: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
发表日期: 2012-06-01
DOI: 10.1111/j.1742-1241.2012.02929.x
卷: 66, 期:6, 页:544-551
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]: General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; STAGE RENAL-DISEASE ; HOMOCYSTEINE-LOWERING THERAPY ; ACUTE MYOCARDIAL-INFARCTION ; CARDIOVASCULAR-DISEASE ; B-VITAMINS ; SECONDARY PREVENTION ; VASCULAR-DISEASE ; TOTAL MORTALITY ; EVENTS
英文摘要:

Aims: There are growing data and a continuing controversy over the efficacy of folic acid supplementation in stroke prevention. We conducted a meta-analysis based on relevant, up-to-date published randomised trials to further examine this issue. Methods: Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of stroke with a fixed-effects model. Results: Overall, folic acid supplementation reduced the risk of stroke by 8% (n = 55,764; RR: 0.92; 95% CI: 0.861.00, p = 0.038). In the 10 trials with no or partial folic acid fortification (n = 43,426), the risk of stroke was reduced by 11% (0.89; 0.820.97, p = 0.010). Within these trials, a greater beneficial effect was observed among trials with a lower percent use of statins [= 80% (median); 0.77; 0.640.92, p = 0.005], and a meta-regression analysis also suggested a positive dose-response relationship between percent use of statins and log-RR for stroke associated with folic acid supplementation (p = 0.013). A daily dose of 0.40.8mg folic acid appeared to be adequate for stroke prevention in comparison with larger doses. In the remaining five trials conducted in populations with folic acid fortification (n = 12,338), folic acid supplementation had no effect on stroke risk (1.03; 0.881.21, p = 0.69). Conclusions: Our analysis indicated that folic acid supplementation is effective in stroke prevention in populations with no or partial folic acid fortification. In addition, a greater beneficial effect was observed among trials with a lower percent use of statins. Our findings underscore the importance of identifying target populations that can particularly benefit from folic acid therapy.

语种: 英语
WOS记录号: WOS:000304189100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64010
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hypertens, Ctr Epidemiol Studies & Clin Trials,Ruijin Hosp, Shanghai 200030, Peoples R China
4.Beijing Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Hlth Examinat Ctr, Beijing, Peoples R China
6.So Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
7.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100730, Peoples R China
8.Fu Wai Hosp, Div Hypertens, Beijing, Peoples R China
9.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Ctr Childhood Origins Dis, Baltimore, MD USA

Recommended Citation:
Huo, Y.,Qin, X.,Wang, J.,et al. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2012,66(6):544-551.
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