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学科主题: 临床医学
题名:
Effect of aliskiren on arterial stiffness, compared with ramipril in patients with mild to moderate essential hypertension
作者: Guo Jian-qiang; Wang Hong-yi; Sun Ning-ling
关键词: aliskiren ; arterial stiffness ; hypertension ; ramipril
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-04-05
DOI: 10.3760/cma.j.issn.0366-6999.20121927
卷: 126, 期:7, 页:1242-1246
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PULSE-WAVE VELOCITY ; RENIN INHIBITOR ALISKIREN ; PLACEBO-LIKE TOLERABILITY ; AORTIC STIFFNESS ; EFFICACY
英文摘要:

Background Aliskiren is a novel blood pressure-lowering agent acting as an oral direct renin inhibitor. The aim of this study was to assess the effect of aliskiren on arterial stiffness, compared with that of ramipril in mild to moderate essential hypertensive patients.

Methods Following a two week placebo run-in period, patients with a mean sitting diastolic blood pressure (ms-DBP) >= 95 and <110 mmHg (1 mmHg=0.133 kPa), and a mean sifting systolic blood pressure (ms-SBP) <180 mmHg were randomly allocated to treatment with aliskiren (150 mg/d, n=20) or ramipril (5 mg/d, n=20) for eight weeks. Blood pressure, plasma renin activity, and the brachial-ankle pulse wave velocity (ba-PWV) were measured before and after eight weeks of treatment.

Results Eight weeks of treatment significantly decreased systolic blood pressure and diastolic blood pressure in both the aliskiren group and ramipril group. The hypotensive effect did not differ between the two groups. Plasma renin activity decreased after aliskiren treatment and increased after ramipril treatment. There was no significant difference in baseline ba-PWV between the aliskiren and ramipril groups (P=0.892). The ba-PWV was significantly reduced in both the aliskiren group (1535 (1405-1666) vs. 1464 (1360-1506) cm/s) (P <0.01) and the ramipril group (1544 (1433-1673) vs. 1447 (1327-1549) cm/s) (P <0.01). No statistically significant difference was found in the decline of ba-PWV between the two groups (P=0.766).

Conclusions The current study revealed that aliskiren (150 mg/d) could ameliorate arterial stiffness and its effect was similar to ramipril (5 mg/d) in mild to moderate hypertensive patients, indicating that in addition to lowering blood pressure, aliskiren had beneficial effect on vascular protection.

语种: 英语
WOS记录号: WOS:000319783800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64018
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Depaitment Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Guo Jian-qiang,Wang Hong-yi,Sun Ning-ling. Effect of aliskiren on arterial stiffness, compared with ramipril in patients with mild to moderate essential hypertension[J]. CHINESE MEDICAL JOURNAL,2013,126(7):1242-1246.
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