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学科主题: 临床医学
题名:
The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma
作者: Wang, Hui; Shen, Luyan; Lin, Yao; Shi, Qi; Yang, Yongbo; Chen, Keneng
关键词: Esophageal squamous cell carcinoma ; mucin 13 ; mucin 20 ; prognosis
刊名: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
发表日期: 2015-08-01
DOI: 10.4103/0973-1482.163846
卷: suppl.S, 期:5, 页:C74-C79
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MUC4/SIALOMUCIN COMPLEX ; MUC20 OVEREXPRESSION ; SURFACE MUCIN ; CANCER ; ACTIVATION ; MUC13 ; TUMOR ; RAS
英文摘要:

Background: Mucin 13 (MUC13) and Mucin 20 (MUC20) are high molecular weight transmembrane O-linked glycoprotein secreted by epithelium and are widely overexpressed in epithelial tumor cells. Previously, it has been reported that MUC13 and MUC20 were prognostic molecular biomarkers of some epithelial tumors, but few has studied the relations between MUC13 or MUC20 expression and the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Thus, the aim of our study was to explore this issue.

Materials and Methods: Immunohistochemistry was used to detect the expressions of MUC13 and MUC20 in 186 patients with ESCC who received neoadjuvant chemotherapy followed by surgery. We analyzed the correlations between MUC13 or MUC20 expression and long-term survival of these patients.

Results: The expression of MUC13 and MUC20 in ESCC mainly occurred in the cytoplasm. Among the 186 subjects, 53.8% had high MUC13 expression and 38.2% had high MUC20 expression. Univariate analysis showed that neither MUC13 nor MUC20 was significantly associated with long-term survival. When combining expression of MUC13 with MUC20, we found that the median survival time of patients with low MUC13/high MUC20 expression was significantly shorter than that of patients with high MUC13/low MUC20 expression (27.7 months vs. 59.5 months, P = 0.021). Multivariate analysis showed that combination of MUC13/MUC20 expression was an independent prognostic factor (hazard ratios = 0.531, 95% confidence interval: 0.299-0.944, P = 0.031).

Conclusion: A combination of MUC13/MUC20 expression was a potential prognostic marker for patients with ESCC, who received neoadjuvant chemotherapy followed by surgery.

语种: 英语
所属项目编号: 2011CB504300 ; 20130001110108 ; 81301748 ; IRT13003 ; xxhz201405
项目资助者: National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Beijing Star of Science and Technology Plan
WOS记录号: WOS:000360955000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64028
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: Peking Univ Canc Hosp & Inst, Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Wang, Hui,Shen, Luyan,Lin, Yao,et al. The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma[J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,2015,suppl.S(5):C74-C79.
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