IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas
Zhao, Yufeng1; Zha, Dingjun1; Wang, Li2; Qiao, Li1; Lu, Lianjun1; Mei, Lin3; Chen, Chen4; Qiu, Jianhua1
关键词GPR120 Pancreas CD68 CD117 CD34
刊名TISSUE & CELL
2013-12-01
DOI10.1016/j.tice.2013.07.005
45期:6页:421-427
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anatomy & Morphology ; Cell Biology
资助者National Natural Science Foundation of China ; scientific research foundation from State Education Ministration of China ; National Natural Science Foundation of China ; scientific research foundation from State Education Ministration of China
研究领域[WOS]Anatomy & Morphology ; Cell Biology
关键词[WOS]GASTROINTESTINAL STROMAL TUMORS ; FATTY-ACIDS ; INSULIN-SECRETION ; GPR120 ; PROTEIN ; CAJAL ; MACROPHAGES ; EXPRESSION ; MOUSE ; DISEASES
英文摘要

GPR120 functions as a plasma membrane receptor for unsaturated long-chain free fatty acids and involves in GLP-1 secretion, adipogenesis and the control of energy balance. Pancreas is the key organ in fuel and energy metabolism. Here GPR120 expression in human and rat pancreas was observed by RT-PCR, and the distribution and phenotypes of GPR120-positive cells in human and rat pancreas were shown by immunohistochemical staining. GPR120 mRNA expression was found in human and rat pancreas. GPR120-positive cells were scattered mainly in the interstitial tissues of human and rat pancreas, and they were not co-localized with nestin, vimentin, alpha-SMA and glucagon, respectively. However, GPR120 was distributed on the cells positively stained by CD68, the specific marker of macrophages, and on the cells positive stained by CD34 and CD117, the markers of interstitial cells. In conclusion, this study demonstrates the expression of GPR120 in pancreas and shows the distribution of GPR120 in human and rat pancreas. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号30971078 ; HG3501
资助者National Natural Science Foundation of China ; scientific research foundation from State Education Ministration of China ; National Natural Science Foundation of China ; scientific research foundation from State Education Ministration of China
WOS记录号WOS:000327775000010
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64032
Collection北京大学第三临床医学院_心血管内科
作者单位1.Fourth Mil Med Univ, Xijing Hosp, Dept Otolaryngol, Xian 710032, Peoples R China
2.Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Nephrol, Xian 710049, Peoples R China
3.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
4.Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Zhao, Yufeng,Zha, Dingjun,Wang, Li,et al. Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas[J]. TISSUE & CELL,2013,45(6):421-427.
APA Zhao, Yufeng.,Zha, Dingjun.,Wang, Li.,Qiao, Li.,Lu, Lianjun.,...&Qiu, Jianhua.(2013).Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas.TISSUE & CELL,45(6),421-427.
MLA Zhao, Yufeng,et al."Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas".TISSUE & CELL 45.6(2013):421-427.
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