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学科主题口腔医学
Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion
Wang, Tianda1; Yang, Sheng1,2; Wang, Lei1; Feng, Hailan1
刊名RSC ADVANCES
2015
DOI10.1039/c4ra14744h
5期:15页:11136-11144
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]DEMINERALIZED HUMAN DENTIN ; CALCIUM-PHOSPHATE ; IN-VITRO ; INTERFACIAL ENERGY ; COLLAGEN FIBRILS ; CRYSTAL-GROWTH ; OSTEOPONTIN ; HYDROXYAPATITE ; SURFACE ; INHIBITION
英文摘要

The disequilibrium between demineralization and remineralization of teeth, especially of dentin, may lead to serious consequences like dental caries that are considered to affect people′s quality of life. The employment of biomimetic analogs of proteins to duplicate biomineralization, which is a well-regulated process mediated by extracellular matrix proteins, may provide new insights to solve these problems. Here we report the use of a modified multifunctional dendrimer, synthesized by the introduction of phosphate groups via a Mannich-type reaction onto poly(amidoamine) (PAMAM) dendrimers, to biomimetically remineralize dentin. The phosphorylated PAMAM dendrimers were demonstrated to act, along with an amorphous calcium phosphate stabilizing agent, polyacrylic acid (PAA), as biomimetic analogs of noncollagenous proteins to induce the remineralization of demineralized dentin. Phosphorylated PAMAM dendrimers treated demineralized dentin discs were immersed in a remineralizing solution containing PAA for up to 7 days. The success of this remineralization was examined using attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) and electron microscopy. These results showed that demineralized dentinal collagen fibrils were successfully phosphorylated by the treatment of phosphorylated PAMAM dendrimers and embedded with calcium-deficient hydroxyapatite after remineralization. The surfaces of demineralized dentin discs were covered with newly induced crystals and the patent dentinal tubules were occluded. A good biocompatibility was also determined. Thus, phosphorylated PAMAM dendrimers could be applied as a minimally invasive method of management of dentin caries, employed to improve the resin-dentin bonding stability and also be used in the treatment of dentin hypersensitivity.

语种英语
WOS记录号WOS:000348986900037
项目编号20100001110092 ; CSTC2012jjA10106 ; NSFC81470770
资助机构Specialized Research Fund for the Doctoral Program of Higher Education of China ; Chongqing Natural Science Foundation ; National Nature Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64035
专题北京大学口腔医学院_口腔修复科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
2.Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Tianda,Yang, Sheng,Wang, Lei,et al. Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion[J]. RSC ADVANCES,2015,5(15):11136-11144.
APA Wang, Tianda,Yang, Sheng,Wang, Lei,&Feng, Hailan.(2015).Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion.RSC ADVANCES,5(15),11136-11144.
MLA Wang, Tianda,et al."Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion".RSC ADVANCES 5.15(2015):11136-11144.
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