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IR@PKUHSC  > 北京大学口腔医学院  > 口腔修复科  > 期刊论文
学科主题: 口腔医学
题名:
Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion
作者: Wang, Tianda1; Yang, Sheng1,2; Wang, Lei1; Feng, Hailan1
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c4ra14744h
卷: 5, 期:15, 页:11136-11144
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: DEMINERALIZED HUMAN DENTIN ; CALCIUM-PHOSPHATE ; IN-VITRO ; INTERFACIAL ENERGY ; COLLAGEN FIBRILS ; CRYSTAL-GROWTH ; OSTEOPONTIN ; HYDROXYAPATITE ; SURFACE ; INHIBITION
英文摘要:

The disequilibrium between demineralization and remineralization of teeth, especially of dentin, may lead to serious consequences like dental caries that are considered to affect people′s quality of life. The employment of biomimetic analogs of proteins to duplicate biomineralization, which is a well-regulated process mediated by extracellular matrix proteins, may provide new insights to solve these problems. Here we report the use of a modified multifunctional dendrimer, synthesized by the introduction of phosphate groups via a Mannich-type reaction onto poly(amidoamine) (PAMAM) dendrimers, to biomimetically remineralize dentin. The phosphorylated PAMAM dendrimers were demonstrated to act, along with an amorphous calcium phosphate stabilizing agent, polyacrylic acid (PAA), as biomimetic analogs of noncollagenous proteins to induce the remineralization of demineralized dentin. Phosphorylated PAMAM dendrimers treated demineralized dentin discs were immersed in a remineralizing solution containing PAA for up to 7 days. The success of this remineralization was examined using attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) and electron microscopy. These results showed that demineralized dentinal collagen fibrils were successfully phosphorylated by the treatment of phosphorylated PAMAM dendrimers and embedded with calcium-deficient hydroxyapatite after remineralization. The surfaces of demineralized dentin discs were covered with newly induced crystals and the patent dentinal tubules were occluded. A good biocompatibility was also determined. Thus, phosphorylated PAMAM dendrimers could be applied as a minimally invasive method of management of dentin caries, employed to improve the resin-dentin bonding stability and also be used in the treatment of dentin hypersensitivity.

语种: 英语
所属项目编号: 20100001110092 ; CSTC2012jjA10106 ; NSFC81470770
项目资助者: Specialized Research Fund for the Doctoral Program of Higher Education of China ; Chongqing Natural Science Foundation ; National Nature Science Foundation of China
WOS记录号: WOS:000348986900037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64035
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
2.Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China

Recommended Citation:
Wang, Tianda,Yang, Sheng,Wang, Lei,et al. Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion[J]. RSC ADVANCES,2015,5(15):11136-11144.
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