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Genetic Etiology and Dental Pulp Cell Deficiency of Hypophosphatasia
Liu, H.1,2; Li, J.1,2; Lei, H.1,2; Zhu, T.1,2; Gan, Y.3,4; Ge, L.1,2
关键词hypophosphatasia tissue-non-specific alkaline phosphatase gene mutation dental pulp cells
刊名JOURNAL OF DENTAL RESEARCH
2010-12-01
DOI10.1177/0022034510379017
89期:12页:1373-1377
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]NONSPECIFIC ALKALINE-PHOSPHATASE ; STRUCTURAL EVIDENCE ; MINERALIZATION ; MUTATIONS ; CULTURES ; TEETH
英文摘要

Hypophosphatasia is caused by mutations of the tissue-non-specific alkaline phosphatase (TNSALP) gene with deficiency of dentin structure. The aim of this study was to examine whether TNSALP mutation in dental pulp cells contributes to dentin dysplasia in hypophosphatasia. Mutation analysis showed that compound heterozygous mutations of TNSALP were identified in three hypophosphatasia patients, including 3 novel mutation sites. Exfoliated teeth from the patients showed abnormal dentin mineralization and loss of cementum, as assessed by ground sections and scanning electron microscope analysis. Dental pulp cells isolated from one of the patients showed a significantly reduced TNSALP activity and mineralization capacity when compared with those in dental pulp cells from the unaffected individuals. Our results suggested that dentin dysplasia in hypophosphatasia may be associated with the decreased mineralization ability of dental pulp cells.

语种英语
所属项目编号30772419
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000284531100006
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64036
专题北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Dept Pediat Dent, Sch Stomatol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Pediat Dent, Hosp Stomatol, Beijing 100871, Peoples R China
3.Peking Univ, Cent Lab, Hosp Stomatol, Beijing 100871, Peoples R China
4.Peking Univ, Cent Lab, Sch Stomatol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, H.,Li, J.,Lei, H.,et al. Genetic Etiology and Dental Pulp Cell Deficiency of Hypophosphatasia[J]. JOURNAL OF DENTAL RESEARCH,2010,89(12):1373-1377.
APA Liu, H.,Li, J.,Lei, H.,Zhu, T.,Gan, Y.,&Ge, L..(2010).Genetic Etiology and Dental Pulp Cell Deficiency of Hypophosphatasia.JOURNAL OF DENTAL RESEARCH,89(12),1373-1377.
MLA Liu, H.,et al."Genetic Etiology and Dental Pulp Cell Deficiency of Hypophosphatasia".JOURNAL OF DENTAL RESEARCH 89.12(2010):1373-1377.
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