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学科主题: 临床医学
题名:
Assessment of therapeutic biomarkers in the treatment of children with postural tachycardia syndrome and vasovagal syncope
作者: Lin, Jing; Jin, Hongfang; Du, Junbao
关键词: Postural tachycardia syndrome ; vasovagal syncope ; therapeutic biomarkers
刊名: CARDIOLOGY IN THE YOUNG
发表日期: 2014-10-01
DOI: 10.1017/S1047951114000316
卷: 24, 期:5, 页:792-796
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Pediatrics
研究领域[WOS]: Cardiovascular System & Cardiology ; Pediatrics
关键词[WOS]: FLOW-MEDIATED VASODILATION ; ORTHOSTATIC TACHYCARDIA ; MIDODRINE HYDROCHLORIDE ; PRO-ADRENOMEDULLIN ; HYDROGEN-SULFIDE ; PLASMA ; INTOLERANCE ; PREDICTOR ; PROPRANOLOL ; ADOLESCENTS
英文摘要:

Background: Postural tachycardia syndrome and vasovagal syncope are common causes of orthostatic intolerance in children. The supplementation with water, or salt, or midodrine, or beta-blocker was applied to children with postural tachycardia syndrome or vasovagal syncope. However, the efficacy of such medication varied and was not satisfied. This review aimed to summarise the current biomarkers in the treatment of the diseases. Data sources: Studies were collected from online electronic databases, including OVID Medline, PubMed, ISI Web of Science, and associated references. The main areas assessed in the included studies were clinical improvement, the cure rate, and the individualised treatment for postural tachycardia syndrome and vasovagal syncope in children. Results: Haemodynamic change during head-up tilt test, and detection of 24-hour urinary sodium excretion, flow-mediated vasodilation, erythrocytic H2S, and plasma pro-adrenomedullin as biological markers were the new ways that were inexpensive, non-invasive, and easy to test for finding those who would be suitable for a specific drug and treatment. Conclusion: With the help of biomarkers, the therapeutic efficacy was greatly increased for children with postural tachycardia syndrome and vasovagal syncope.

语种: 英语
所属项目编号: 2012BAI03B03
项目资助者: National Twelfth Five-Year Plan for Science &amp ; Technology Support
WOS记录号: WOS:000346331200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64040
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Lin, Jing,Jin, Hongfang,Du, Junbao. Assessment of therapeutic biomarkers in the treatment of children with postural tachycardia syndrome and vasovagal syncope[J]. CARDIOLOGY IN THE YOUNG,2014,24(5):792-796.
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