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学科主题临床医学
Arg347Cys polymorphism of alpha 1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients
Zhang, Yan2; Hong, Xiumei1; Liu, Haipeng1; Huo, Yong2; Xu, Xiping1
关键词adrenoceptor blood pressure hypertension nifedipine polymorphism response
刊名JOURNAL OF HUMAN GENETICS
2009-06-01
DOI10.1038/jhg.2009.42
54期:6页:360-364
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]HUMAN BETA-2-ADRENERGIC RECEPTOR ; BETA(2)-ADRENERGIC RECEPTOR ; PHARMACOLOGICAL CHARACTERIZATION ; ALPHA-ADDUCIN ; SMOOTH-MUSCLE ; RENAL-ARTERY ; SYSTEM ; ALPHA(1)-ADRENOCEPTORS ; DESENSITIZATION ; INDIVIDUALS
英文摘要

Our objectives were to evaluate whether polymorphisms in the alpha 1A- and beta 2-adrenoceptor genes influence blood pressure response to nifedipine gastrointestinal therapeutic system (GITS). Hypertensive patients received daily treatment with an oral dosage of 30 mg nifedipine GITS for 16 days. Genotypes of the Arg347Cys polymorphism in the alpha 1A-adrenoceptor gene and the Arg16Gly and Gln27Glu polymorphisms in the beta 2-adrenoceptor gene were determined by TaqMan single-nucleotide polymorphism genotyping assay. The sixteenth-day steady-state plasma concentration of nifedipine was measured using HPLC with UV detection. Multivariate linear regression was performed in a total of 447 patients to evaluate the effects of these polymorphisms on blood pressure response to nifedipine GITS. Patients carrying the Cys347 allele of the alpha 1A-adrenoceptor gene had a greater systolic blood pressure reduction than did those carrying two Arg347 alleles of the alpha 1A-adrenoceptor gene (32.5 +/- 14.0 versus 27.3 +/- 15.5 mm Hg, respectively, P=0.006). However, diastolic blood pressure reduction was not associated with the Arg347Cys polymorphism in the alpha 1A-adrenoceptor gene. In addition, no significant associations were observed between blood pressure reduction and two polymorphisms in the beta 2-adrenoceptor gene. Our data suggest that the Arg347Cys polymorphism in the alpha 1A-adrenoceptor gene may be used to predict blood pressure response to nifedipine GITS in Chinese hypertensive patients. Journal of Human Genetics (2009) 54, 360-364; doi:10.1038/jhg.2009.42; published online 15 May 2009

语种英语
WOS记录号WOS:000268312700009
资助机构Anhui Provincial Ministry of Education ; Anhui Medical University Biomedical Institute
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64047
专题北京大学第一临床医学院_心血管内科
作者单位1.Anhui Med Univ, Inst Biomed, Hefei 230032, Anhui, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yan,Hong, Xiumei,Liu, Haipeng,et al. Arg347Cys polymorphism of alpha 1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients[J]. JOURNAL OF HUMAN GENETICS,2009,54(6):360-364.
APA Zhang, Yan,Hong, Xiumei,Liu, Haipeng,Huo, Yong,&Xu, Xiping.(2009).Arg347Cys polymorphism of alpha 1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients.JOURNAL OF HUMAN GENETICS,54(6),360-364.
MLA Zhang, Yan,et al."Arg347Cys polymorphism of alpha 1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients".JOURNAL OF HUMAN GENETICS 54.6(2009):360-364.
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