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学科主题基础医学
Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems
Zhang, Yang2,3; Wang, Ning1; Wang, Jin-Yan1; Chang, Jing-Yu4; Woodward, Donald J.4; Luo, Fei1,2,3
关键词Laser Intensity Pain Single unit Ensemble encoding
刊名MOLECULAR PAIN
2011-08-24
DOI10.1186/1744-8069-7-64
7期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PRIMARY SOMATOSENSORY CORTEX ; ANTERIOR CINGULATE CORTEX ; C-FIBER INPUT ; BRAIN RESPONSES ; NEURONS ; DISCRIMINATION ; PATHWAYS ; SI ; PERCEPTION ; THALAMUS
英文摘要

Background: The ability to encode noxious stimulus intensity is essential for the neural processing of pain perception. It is well accepted that the intensity information is transmitted within both sensory and affective pathways. However, it remains unclear what the encoding patterns are in the thalamocortical brain regions, and whether the dual pain systems share similar responsibility in intensity coding.

Results: Multichannel single-unit recordings were used to investigate the activity of individual neurons and neuronal ensembles in the rat brain following the application of noxious laser stimuli of increasing intensity to the hindpaw. Four brain regions were monitored, including two within the lateral sensory pain pathway, namely, the ventral posterior lateral thalamic nuclei and the primary somatosensory cortex, and two in the medial pathway, namely, the medial dorsal thalamic nuclei and the anterior cingulate cortex. Neuron number, firing rate, and ensemble spike count codings were examined in this study. Our results showed that the noxious laser stimulation evoked double-peak responses in all recorded brain regions. Significant correlations were found between the laser intensity and the number of responsive neurons, the firing rates, as well as the mass spike counts (MSCs). MSC coding was generally more efficient than the other two methods. Moreover, the coding capacities of neurons in the two pathways were comparable.

Conclusion: This study demonstrated the collective contribution of medial and lateral pathway neurons to the noxious intensity coding. Additionally, we provide evidence that ensemble spike count may be the most reliable method for coding pain intensity in the brain.

语种英语
WOS记录号WOS:000295594000001
项目编号30700223 ; 30570577 ; 30770688 ; 30970959 ; 61033011 ; KSCX2-EW-Q-18 ; KSCX2-YW-R-254 ; KSCX2-EW-J-8 ; TW008038
资助机构NNSF ; CAS ; NIH
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64053
专题北京大学基础医学院_神经生物学系
作者单位1.Neurosci Res Inst N Carolina, Winston Salem, NC USA
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yang,Wang, Ning,Wang, Jin-Yan,et al. Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems[J]. MOLECULAR PAIN,2011,7(1).
APA Zhang, Yang,Wang, Ning,Wang, Jin-Yan,Chang, Jing-Yu,Woodward, Donald J.,&Luo, Fei.(2011).Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems.MOLECULAR PAIN,7(1).
MLA Zhang, Yang,et al."Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems".MOLECULAR PAIN 7.1(2011).
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