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学科主题: 基础医学
题名:
Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems
作者: Zhang, Yang2,3; Wang, Ning1; Wang, Jin-Yan1; Chang, Jing-Yu4; Woodward, Donald J.4; Luo, Fei1,2,3
关键词: Laser ; Intensity ; Pain ; Single unit ; Ensemble encoding
刊名: MOLECULAR PAIN
发表日期: 2011-08-24
DOI: 10.1186/1744-8069-7-64
卷: 7, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PRIMARY SOMATOSENSORY CORTEX ; ANTERIOR CINGULATE CORTEX ; C-FIBER INPUT ; BRAIN RESPONSES ; NEURONS ; DISCRIMINATION ; PATHWAYS ; SI ; PERCEPTION ; THALAMUS
英文摘要:

Background: The ability to encode noxious stimulus intensity is essential for the neural processing of pain perception. It is well accepted that the intensity information is transmitted within both sensory and affective pathways. However, it remains unclear what the encoding patterns are in the thalamocortical brain regions, and whether the dual pain systems share similar responsibility in intensity coding.

Results: Multichannel single-unit recordings were used to investigate the activity of individual neurons and neuronal ensembles in the rat brain following the application of noxious laser stimuli of increasing intensity to the hindpaw. Four brain regions were monitored, including two within the lateral sensory pain pathway, namely, the ventral posterior lateral thalamic nuclei and the primary somatosensory cortex, and two in the medial pathway, namely, the medial dorsal thalamic nuclei and the anterior cingulate cortex. Neuron number, firing rate, and ensemble spike count codings were examined in this study. Our results showed that the noxious laser stimulation evoked double-peak responses in all recorded brain regions. Significant correlations were found between the laser intensity and the number of responsive neurons, the firing rates, as well as the mass spike counts (MSCs). MSC coding was generally more efficient than the other two methods. Moreover, the coding capacities of neurons in the two pathways were comparable.

Conclusion: This study demonstrated the collective contribution of medial and lateral pathway neurons to the noxious intensity coding. Additionally, we provide evidence that ensemble spike count may be the most reliable method for coding pain intensity in the brain.

语种: 英语
所属项目编号: 30700223 ; 30570577 ; 30770688 ; 30970959 ; 61033011 ; KSCX2-EW-Q-18 ; KSCX2-YW-R-254 ; KSCX2-EW-J-8 ; TW008038
项目资助者: NNSF ; CAS ; NIH
WOS记录号: WOS:000295594000001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64053
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Neurosci Res Inst N Carolina, Winston Salem, NC USA
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Yang,Wang, Ning,Wang, Jin-Yan,et al. Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems[J]. MOLECULAR PAIN,2011,7(1).
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