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学科主题: 临床医学
题名:
IL-6 gene polymorphisms and CAD risk: a meta-analysis
作者: Yang, Yuan1; Zhang, Fan2; Skrip, Laura3; Lei, Han1; Wang, Yang2; Hu, Dayi1; Ding, Rongjing4
关键词: IL-6 gene ; -174 G/C ; -572 G/C ; Polymorphism ; Coronary artery disease
刊名: MOLECULAR BIOLOGY REPORTS
发表日期: 2013-03-01
DOI: 10.1007/s11033-012-2345-x
卷: 40, 期:3, 页:2589-2598
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CORONARY-ARTERY-DISEASE ; ACUTE MYOCARDIAL-INFARCTION ; G/C PROMOTER POLYMORPHISM ; C-REACTIVE PROTEIN ; INTERLEUKIN-6 GENE ; HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; NO ASSOCIATION ; INFLAMMATION ; PLASMA
英文摘要:

The potential relationship between Interleukin-6 (IL-6) gene polymorphisms and coronary artery disease (CAD) has been widely investigated. However, study findings on the -174 G/C and -572 G/C variants remain inconsistent and somewhat controversial. The present meta-analysis was conducted in an attempt to provide a more robust synthesis conclusion. PubMed and Embase were used to search for all relevant studies published on or before May 22, 2012. A total of 19 studies were ultimately included in the analysis. Overall combined risk was calculated with fixed or random-effects models. Subgroup and sensitivity analyses were performed. Among the included studies, no statistically significant differences were found between controls and CAD cases for the G allele contrasts of the -174 G/C and -572 G/C polymorphisms. The co-dominant genetic model was evaluated for the -174 G/C polymorphism. A significant association was detected using GG versuss CC (OR = 0.801, 95 % CI: [0.652, 0.983], P = 0.034). However, the association was not obviously in subgroup analysis by ethnicity. The recessive genetic model was evaluated for the -572 G/C polymorphism. The relationship between -572 G/C polymorphism and CAD risk was only found to be significant in Asian populations (random-effects: OR = 1.908, 95 % CI: [1.016, 3.581], P = 0.044) using GG versus GC+CC. No obvious publication bias was found by Begg′s funnel plots and the Egger′s linear regression test (P = 0.315 for -174 G/C polymorphism and P = 0.118 for -572 G/C polymorphism). Our study indicated that the association between the IL-6 gene and CAD risk was mild and moderate for the -174 G/C and -572 G/C polymorphisms. However, this relationship requires additional investigation through well-designed studies with larger sample sizes.

语种: 英语
WOS记录号: WOS:000314535600058
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64055
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Yale Univ, Sch Publ Hlth, New Haven, CT 06520 USA
2.Chongqing Med Univ, Dept Cardiol, Chongqing 400016, Peoples R China
3.Chongqing Med Univ, Sch Publ Hlth & Hlth Management, Chongqing 400016, Peoples R China
4.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China

Recommended Citation:
Yang, Yuan,Zhang, Fan,Skrip, Laura,et al. IL-6 gene polymorphisms and CAD risk: a meta-analysis[J]. MOLECULAR BIOLOGY REPORTS,2013,40(3):2589-2598.
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