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学科主题临床医学
Epileptic seizures in patients following allogeneic hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors, and survival rates
Zhang, Xiao-hui; Xu, Lan-ping; Liu, Dai-hong; Chen, Huan; Han, Wei; Chen, Yu-hong; Wang, Feng-rong; Wang, Jing-zhi; Wang, Yu; Zhao, Ting; Chen, Yao; Fu, Hai-xia; Liu, Kai-yan; Huang, Xiao-jun
关键词allogeneic epileptic seizures risk factors stem cell transplant survival
刊名CLINICAL TRANSPLANTATION
2013
DOI10.1111/ctr.12000
27期:1页:80-89
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; NERVOUS-SYSTEM COMPLICATIONS ; NEUROLOGIC COMPLICATIONS ; CHILDREN ; MANIFESTATIONS ; PROGNOSIS ; LEUKEMIA
英文摘要

The incidence of epileptic seizures among allogeneic hematopoietic stem cell transplant (allo-HSCT) patients has been poorly described. No report has systematically studied epilepsy′s possible causes, risk factors, and effect on prognosis among allo-HSCT patients. We retrospectively examined data from 1461 patients who underwent allo-HSCT within the past 6.5 yr at the Institute of Hematology and People′s Hospital, Peking University. The cumulative incidence of all epileptic seizure complications was 7.1%. Of the 79 transplant patients who had epileptic seizures, 3 (3.8%) experienced a seizure during the conditioning stage, 52 (65.8%) between day 0 and day 100, 20 (25.3%) from day 100 to the first year, and 4 (5.1%) after the first year. Multivariate regression analysis identified the age of the recipient as (=18 yr) (p < 0.001), donor type (p = 0.004), graft versus host disease (aGVHD) (p = 0.018), and hyponatremia (p = 0.003) as independent risk factors for epileptic seizures among allo-HSCT patients. The median survival time of patients with epileptic seizures was 246 d after transplantation (ranging between 18 and 2170 d). Survival after one yr and 6.5 yr was significantly reduced in patients who developed epileptic seizure complications compared with those who did not (57.2% vs. 75.7% at one yr, p = 0.015, and 31.1% vs. 71.4% at five yr, p < 0.001). Of the 79 patients who experienced epileptic seizure complications, 53.2% died (n = 42). The survival rate of these patients was relatively low, and cerebrovascular disorders or central nervous system infection-related epileptic seizures usually resulted in a high mortality and poor prognosis. A patient transplantation age which is younger than 18 yr, related mismatched transplants, aGVHD, and hyponatremia are risk factors for epileptic seizures in allo-HSCT recipients. Epileptic seizures among allo-HSCT patients are associated with a poor prognosis.

语种英语
WOS记录号WOS:000314208000021
项目编号81070449 ; 7112139 ; 2012BAI38B03 ; Z111107058811024
资助机构National Natural Science Foundation of China ; National Science Foundation of Beijing ; National Key Technology Support Program ; Capital Clinical characteristic application foundation
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64059
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiao-hui,Xu, Lan-ping,Liu, Dai-hong,et al. Epileptic seizures in patients following allogeneic hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors, and survival rates[J]. CLINICAL TRANSPLANTATION,2013,27(1):80-89.
APA Zhang, Xiao-hui.,Xu, Lan-ping.,Liu, Dai-hong.,Chen, Huan.,Han, Wei.,...&Huang, Xiao-jun.(2013).Epileptic seizures in patients following allogeneic hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors, and survival rates.CLINICAL TRANSPLANTATION,27(1),80-89.
MLA Zhang, Xiao-hui,et al."Epileptic seizures in patients following allogeneic hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors, and survival rates".CLINICAL TRANSPLANTATION 27.1(2013):80-89.
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