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学科主题临床医学
Knee osteoarthritis and all-cause mortality: the Wuchuan Osteoarthritis Study
Liu, Q.1,2; Niu, J.3; Huang, J.4; Ke, Y.1,2; Tang, X.1,2; Wu, X.1,2; Li, R.1,2; Li, H.1,2; Zhi, X.1,2; Wang, K.1,2; Zhang, Y.3; Lin, J.1,2
关键词Knee osteoarthritis Mortality Cohort study
刊名OSTEOARTHRITIS AND CARTILAGE
2015-07-01
DOI10.1016/j.joca.2015.03.021
23期:7页:1154-1157
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics ; Rheumatology
研究领域[WOS]Orthopedics ; Rheumatology
关键词[WOS]CHINESE POPULATION ; UNITED-STATES ; PREVALENCE ; DISEASE ; COHORT ; RISK
英文摘要

Background: Previous studies showed that knee osteoarthritis (OA) is associated with increased mortality in Caucasians. While prevalence of knee OA is higher in Chinese than in Caucasians, no study has examined whether knee OA increases mortality in Chinese population.

Methods: Between 8/2005-10/2005 1025 residents aged >= 50 years were recruited in randomly selected rural communities in Wuchuan, China. Subjects completed a home interview and had weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral joints and skyline view of radiographs at patellofemoral joints, and were followed until end of 2013. A knee was defined as having radiographic osteoarthritis (ROA) if either Kellgren/Lawrence (KL) score at tibiofemoral joint >= 2 or presence of OA at patellofemoral joint based on OARSI criteria. Symptomatic knee osteoarthritis (SxOA) was defined if both pain (i.e., knee pain occurred on most days in past month) and ROA were present at the same knee. We examined the relation of knee SxOA and knee ROA to the all-cause mortality, respectively, using Cox-proportional hazard models adjusting for potential confounders.

Results: Over the follow-up period 99 subjects died. The mortality rates were 32.6 (95% confidence interval (CI): 19.6-54.0) and 10.9 (95% CI: 8.8-13.5) per 1000 person-years among subjects with and without SxOA, respectively. Multivariable adjusted hazard ratio of all-cause mortality for knee SxOA was 1.9 (95% CI: 1.0-3.5). However, no such association was observed for knee ROA (hazard ratio = 1.2, 95% CI: 0.7-1.9).

Conclusions: Knee SxOA was associated with an increased risk of all-cause mortality among the residents in the rural areas of China. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000356446300016
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64060
专题北京大学第二临床医学院
北京大学公共卫生学院_流行病与卫生统计学系
北京大学护理学院_护理学院
北京大学第二临床医学院_放射科
北京大学临床肿瘤学院_遗传学研究室
作者单位1.Peking Univ, Peoples Hosp, Arthrit Clin, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Res Ctr, Beijing 100871, Peoples R China
3.Boston Univ, Dept Med, Boston Med Ctr, Clin Epidemiol Res & Training Unit, Boston, MA 02215 USA
4.Inner Mongolia Med Univ, Affiliated Hosp 2, Dept Orthoped Surg, Inner Mongolia, Peoples R China
推荐引用方式
GB/T 7714
Liu, Q.,Niu, J.,Huang, J.,et al. Knee osteoarthritis and all-cause mortality: the Wuchuan Osteoarthritis Study[J]. OSTEOARTHRITIS AND CARTILAGE,2015,23(7):1154-1157.
APA Liu, Q..,Niu, J..,Huang, J..,Ke, Y..,Tang, X..,...&Lin, J..(2015).Knee osteoarthritis and all-cause mortality: the Wuchuan Osteoarthritis Study.OSTEOARTHRITIS AND CARTILAGE,23(7),1154-1157.
MLA Liu, Q.,et al."Knee osteoarthritis and all-cause mortality: the Wuchuan Osteoarthritis Study".OSTEOARTHRITIS AND CARTILAGE 23.7(2015):1154-1157.
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