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学科主题基础医学
Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases
He, Huiying3; Ring, Weigang3; Liu, Xiyong2; Weiss, Laivrence M.; Chu, Peiguo G.1
关键词glypican-3 Merkel cell carcinoma small cell neuroendocrine carcinoma immunohistochemistry
刊名APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
2009
17期:1页:40-46
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]TRANSCRIPTION FACTOR-I ; HUMAN HEPATOCELLULAR-CARCINOMA ; ALPHA-FETOPROTEIN ; CYTOKERATIN 20 ; NEUROENDOCRINE TUMORS ; ONCOFETAL PROTEIN ; LIVER-TUMORS ; WILMS-TUMOR ; MARKER ; SKIN
英文摘要

The pathologic diagnosis of Merkel cell carcinoma (MCC) is mainly based on routine morphology and a characteristic cytokeratin 20 (CK20) immunohistochemical staining pattern. However, about 10% to 15% of MCCs are reportedly CK20 negative and about 10% to 20% of MCCs have only focal CK20 positivity. We aimed to study glypican-3 (GPC3) expression in MCC and to compare it with CK20 expression in MCC. Immunohistochemical expression of GPC-3, CK20, and CD23 were studied in 55 cases of MCC and 21 cases of noncutaneous small cell neuroendocrine carcinoma (SCNC). including 10 cases Of Pulmonary SCNC and I I cases of nonpulmonary SCNC. The results of GPC3 expression in these tumors were then compared with that of CK20. Of the 55 cases, 39 were positive for GPC3 (70.9%). Seventy-seven percent of the positive MCCs (30/39) showed GPC3 immunoreactivity in >= 30% tumor cells. Of the 55 cases, 53 were positive for CK20 (96%); 49 of them showed CK20 immunoreactivity in >= 30% tumor cells. All MCC cases were either positive for both GPC3 and CK20 (37 cases) or at least 1 of the markers (18 cases, 16 CK20 only and 2 GPC3 only). In addition, we studied GPC3 and CK20 expression in 10 cases of pulmonary SCNC and 11 cases of nonpulmonary SCNC. Three of ten pulmonary SCNC and 5 of 11 nonpulmonary SCNC expressed GPC3. All pulmonary SCNC and 9 of 11 nonpulmonary SCNC were negative for CK20. All cases of MCC and SCNC, were negative for CD23. In conclusion, GPC3 is frequently expressed in SCNC of various origins, in particular in MCC, which, in combination with CK20, may represent another useful marker in the diagnosis of MCC.

语种英语
WOS记录号WOS:000262026600007
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/64061
专题北京大学基础医学院_病理学系
北京大学基础医学院
作者单位1.City Hope Natl Med Ctr, Dept Pathol, Div Pathol, Duarte, CA 91010 USA
2.City Hope Natl Med Ctr, Div Clin & Mol Pharmacol, Duarte, CA 91010 USA
3.Beijing Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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He, Huiying,Ring, Weigang,Liu, Xiyong,et al. Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases[J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,2009,17(1):40-46.
APA He, Huiying,Ring, Weigang,Liu, Xiyong,Weiss, Laivrence M.,&Chu, Peiguo G..(2009).Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases.APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,17(1),40-46.
MLA He, Huiying,et al."Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases".APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 17.1(2009):40-46.
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