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Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
Zhang, Xiang Yang1,2,3,4; Zhou, Dong Feng1; Shen, Yu Cun1; Zhang, Pei Yan4; Zhang, Wu Fang1; Liang, Jun1; Chen, Da Chun4; Xiu, Mei Hong4; Kosten, Therese A.2; Kosten, Thomas R.2
关键词Schizophrenia Free radical Oxidative stress Antipsychotic treatment
刊名NEUROPHARMACOLOGY
2012-04-01
DOI10.1016/j.neuropharm.2011.12.014
62期:5-6页:1928-1934
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]ANTIOXIDANT DEFENSE SYSTEM ; ACID-REACTIVE SUBSTANCES ; POLYUNSATURATED FATTY-ACIDS ; FREE-RADICAL PATHOLOGY ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; RAT-BRAIN ; ANTIPSYCHOTIC-DRUGS ; THERAPEUTIC IMPLICATIONS ; ATYPICAL ANTIPSYCHOTICS
英文摘要

Oxidative stress may be involved in the pathophysiology of schizophrenia. No double-blind study has compared the effects of typical and atypical antipsychotics on both antioxidant enzyme activity and nitric oxide (NO) levels in schizophrenic patients. Seventy-eight inpatients with chronic schizophrenia were randomly assigned to 12 weeks of treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol using a double-blind design. Clinical efficacy was determined using the Positive and Negative Syndrome Scale. Blood superoxide dismutase (SOD) and plasma NO levels were measured in patients and 30 normal controls. Our results showed that following a 2-week washout period, levels of SOD and NO were significantly increased in patients with schizophrenia compared to normal controls. Both risperidone and haloperidol equivalently reduced the elevated blood SOD levels in schizophrenia, but neither medication reduced the elevated plasma NO levels in schizophrenia. Low blood SOD levels at baseline predicted greater symptom improvement during treatment, and greater change in SOD was correlated with greater symptom improvement. These results suggest that both typical and atypical antipsychotic drugs may at least partially normalize abnormal free radical metabolism in schizophrenia, and some free radical parameters at baseline may predict antipsychotic responses of schizophrenic patients. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000301474300003
项目编号03T-459 ; 05T-726 ; 7072035 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
资助机构Stanley Medical Research Institute ; Beijing Municipal Natural Science Foundation ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC),United States National Institute of Health
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64062
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Zhou, Dong Feng,Shen, Yu Cun,et al. Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia[J]. NEUROPHARMACOLOGY,2012,62(5-6):1928-1934.
APA Zhang, Xiang Yang.,Zhou, Dong Feng.,Shen, Yu Cun.,Zhang, Pei Yan.,Zhang, Wu Fang.,...&Kosten, Thomas R..(2012).Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia.NEUROPHARMACOLOGY,62(5-6),1928-1934.
MLA Zhang, Xiang Yang,et al."Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia".NEUROPHARMACOLOGY 62.5-6(2012):1928-1934.
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