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学科主题: 精神卫生
题名:
Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
作者: Zhang, Xiang Yang1,2,3,4; Zhou, Dong Feng1; Shen, Yu Cun1; Zhang, Pei Yan4; Zhang, Wu Fang1; Liang, Jun1; Chen, Da Chun4; Xiu, Mei Hong4; Kosten, Therese A.2; Kosten, Thomas R.2
关键词: Schizophrenia ; Free radical ; Oxidative stress ; Antipsychotic treatment
刊名: NEUROPHARMACOLOGY
发表日期: 2012-04-01
DOI: 10.1016/j.neuropharm.2011.12.014
卷: 62, 期:5-6, 页:1928-1934
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: ANTIOXIDANT DEFENSE SYSTEM ; ACID-REACTIVE SUBSTANCES ; POLYUNSATURATED FATTY-ACIDS ; FREE-RADICAL PATHOLOGY ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; RAT-BRAIN ; ANTIPSYCHOTIC-DRUGS ; THERAPEUTIC IMPLICATIONS ; ATYPICAL ANTIPSYCHOTICS
英文摘要:

Oxidative stress may be involved in the pathophysiology of schizophrenia. No double-blind study has compared the effects of typical and atypical antipsychotics on both antioxidant enzyme activity and nitric oxide (NO) levels in schizophrenic patients. Seventy-eight inpatients with chronic schizophrenia were randomly assigned to 12 weeks of treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol using a double-blind design. Clinical efficacy was determined using the Positive and Negative Syndrome Scale. Blood superoxide dismutase (SOD) and plasma NO levels were measured in patients and 30 normal controls. Our results showed that following a 2-week washout period, levels of SOD and NO were significantly increased in patients with schizophrenia compared to normal controls. Both risperidone and haloperidol equivalently reduced the elevated blood SOD levels in schizophrenia, but neither medication reduced the elevated plasma NO levels in schizophrenia. Low blood SOD levels at baseline predicted greater symptom improvement during treatment, and greater change in SOD was correlated with greater symptom improvement. These results suggest that both typical and atypical antipsychotic drugs may at least partially normalize abnormal free radical metabolism in schizophrenia, and some free radical parameters at baseline may predict antipsychotic responses of schizophrenic patients. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 03T-459 ; 05T-726 ; 7072035 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
项目资助者: Stanley Medical Research Institute ; Beijing Municipal Natural Science Foundation ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC),United States National Institute of Health
WOS记录号: WOS:000301474300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64062
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Zhou, Dong Feng,Shen, Yu Cun,et al. Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia[J]. NEUROPHARMACOLOGY,2012,62(5-6):1928-1934.
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