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Changes in monoclonal HLA-DR antigen expression in acute organophosphorus pesticide-poisoned patients
Xia, Chenyun1; Wang, Mi2; Liang, Qi1; Yun, Ling′ an1; Kang, Housheng1; Fan, Lei1; Wang, Dongsheng1; Zhang, Guoyuan1
关键词acute organophosphate pesticide poisoning multiple organ dysfunction syndrome human leukocyte antigen-DR
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2014
DOI10.3892/etm.2013.1356
7期:1页:137-140
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]CLASS-II EXPRESSION ; TRAUMA ; CELLS ; DISEASE ; SEPSIS ; IMMUNOPARALYSIS ; MONOCYTES ; INFECTION ; SURGERY ; ALPHA
英文摘要

The aim of this study was to investigate changes in human leukocyte antigen (HLA)-DR expression of peripheral blood mononuclear cells (MNCs) in patients with acute organophosphorus pesticide poisoning (AOPP). HLA-DR antigen expression of peripheral blood MNCs was examined in 75 patients with AOPP, including 36 patients without multiple organ dysfunction syndrome (non-MODS) and 39 patients with multiple organ dysfunction syndrome (MODS), as well as in 30 healthy individuals using flow cytometry assay. The associations between HLA-DR antigen expression and certain parameters were analyzed, including acute physiology and chronic health evaluation II (APACHE II) score, serum cholinesterase (ChE) activity, cardiac troponin I (cTnI), cardiac enzymes, and liver and kidney function. The mean fluorescence intensity (MCF) of HLA-DR expression in the AOPP group (21.59 +/- 5.36) was significantly lower than that in the control group (27.85 +/- 4.86) (P<0.001). The MCF in the MODS group (18.17 +/- 4.23) was lower than that in the non-MODS group (25.15 +/- 6.15). In addition, the MCF of the deceased patients (15.29 +/- 3.97) was lower than that of the surviving patients (22.34 +/- 2.76) (P<0.001). The MCF of patients with AOPP and MODS was positively correlated with serum ChE (P<0.01) and negatively correlated with the APACHE II score, creatine kinase isoenzyme, cTnI, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen and serum creatinine (P<0.05). In conclusion, HLA-DR expression in patients with AOPP was significantly decreased compared with that in healthy individuals; HLA-DR expression may therefore be a good indicator for evaluating AOPP, MODS disease severity, immune function, efficacy of prognosis and prognosis. Examination of HLA-DR antigen expression may be of crucial clinical value.

语种英语
WOS记录号WOS:000330787500025
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64067
专题北京大学第二临床医学院
北京大学第二临床医学院_肾内科
作者单位1.North Sichuan Med Coll, Affiliated Hosp, Nanchong 637000, Sichuan, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Nephropathy, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xia, Chenyun,Wang, Mi,Liang, Qi,et al. Changes in monoclonal HLA-DR antigen expression in acute organophosphorus pesticide-poisoned patients[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2014,7(1):137-140.
APA Xia, Chenyun.,Wang, Mi.,Liang, Qi.,Yun, Ling&prime.,an.,...&Zhang, Guoyuan.(2014).Changes in monoclonal HLA-DR antigen expression in acute organophosphorus pesticide-poisoned patients.EXPERIMENTAL AND THERAPEUTIC MEDICINE,7(1),137-140.
MLA Xia, Chenyun,et al."Changes in monoclonal HLA-DR antigen expression in acute organophosphorus pesticide-poisoned patients".EXPERIMENTAL AND THERAPEUTIC MEDICINE 7.1(2014):137-140.
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