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学科主题: 临床医学
题名:
Changes in monoclonal HLA-DR antigen expression in acute organophosphorus pesticide-poisoned patients
作者: Xia, Chenyun1; Wang, Mi2; Liang, Qi1; Yun, Ling′ an1; Kang, Housheng1; Fan, Lei1; Wang, Dongsheng1; Zhang, Guoyuan1
关键词: acute organophosphate pesticide poisoning ; multiple organ dysfunction syndrome ; human leukocyte antigen-DR
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2014
DOI: 10.3892/etm.2013.1356
卷: 7, 期:1, 页:137-140
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CLASS-II EXPRESSION ; TRAUMA ; CELLS ; DISEASE ; SEPSIS ; IMMUNOPARALYSIS ; MONOCYTES ; INFECTION ; SURGERY ; ALPHA
英文摘要:

The aim of this study was to investigate changes in human leukocyte antigen (HLA)-DR expression of peripheral blood mononuclear cells (MNCs) in patients with acute organophosphorus pesticide poisoning (AOPP). HLA-DR antigen expression of peripheral blood MNCs was examined in 75 patients with AOPP, including 36 patients without multiple organ dysfunction syndrome (non-MODS) and 39 patients with multiple organ dysfunction syndrome (MODS), as well as in 30 healthy individuals using flow cytometry assay. The associations between HLA-DR antigen expression and certain parameters were analyzed, including acute physiology and chronic health evaluation II (APACHE II) score, serum cholinesterase (ChE) activity, cardiac troponin I (cTnI), cardiac enzymes, and liver and kidney function. The mean fluorescence intensity (MCF) of HLA-DR expression in the AOPP group (21.59 +/- 5.36) was significantly lower than that in the control group (27.85 +/- 4.86) (P<0.001). The MCF in the MODS group (18.17 +/- 4.23) was lower than that in the non-MODS group (25.15 +/- 6.15). In addition, the MCF of the deceased patients (15.29 +/- 3.97) was lower than that of the surviving patients (22.34 +/- 2.76) (P<0.001). The MCF of patients with AOPP and MODS was positively correlated with serum ChE (P<0.01) and negatively correlated with the APACHE II score, creatine kinase isoenzyme, cTnI, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen and serum creatinine (P<0.05). In conclusion, HLA-DR expression in patients with AOPP was significantly decreased compared with that in healthy individuals; HLA-DR expression may therefore be a good indicator for evaluating AOPP, MODS disease severity, immune function, efficacy of prognosis and prognosis. Examination of HLA-DR antigen expression may be of crucial clinical value.

语种: 英语
WOS记录号: WOS:000330787500025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64067
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.North Sichuan Med Coll, Affiliated Hosp, Nanchong 637000, Sichuan, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Nephropathy, Beijing 100044, Peoples R China

Recommended Citation:
Xia, Chenyun,Wang, Mi,Liang, Qi,et al. Changes in monoclonal HLA-DR antigen expression in acute organophosphorus pesticide-poisoned patients[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2014,7(1):137-140.
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