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学科主题: 基础医学
题名:
Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated
作者: Wang, Gui-Bin; Wu, Liu-Zhen; Yu, Peng; Li, Yi-Jing; Ping, Xing-Jie; Cui, Cai-Lian
关键词: Morphine dependence ; Withdrawal ; Electroacupuncture ; Preprodynorphin ; Preproenkephalin ; p-CREB
刊名: PEPTIDES
发表日期: 2011-04-01
DOI: 10.1016/j.peptides.2010.12.006
卷: 32, 期:4, 页:713-721
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: ELEMENT-BINDING PROTEIN ; BLOOD MONONUCLEAR-CELLS ; PERIAQUEDUCTAL GRAY ; OPIATE DEPENDENCE ; ENDOGENOUS ENKEPHALINS ; DIFFERENT FREQUENCIES ; PRODYNORPHIN GENE ; LOCUS-COERULEUS ; HEROIN-ADDICTS ; DYNORPHIN-A
英文摘要:

Alleviating opiate withdrawal syndrome in addicts is a critical precondition to break away from drug and further to prevent reuse. Electroacupuncture (EA) was claimed to be effective for alleviating withdrawal syndrome, but the optimal protocol remained unclear. In the present study we found that (1) 100 Hz EA administered 12-24 h after the last morphine injection suppressed the withdrawal syndrome in rats, multiple sessions of EA were more effective than single session, with the after-effect lasting for at least 7 days. (2) A down-regulation of preprodynorphin (PPD) mRNA level was observed in spinal cord. PAG and hypothalamus 60 h after the last morph: ne injection, which could be reversed by multiple sessions, but cot a single session of EA. (3) Accompanied with the decrease of PPD mRNA level, there was an up-regulation of p-CREB in the three CNS regions, which was abolished by 100 Hz EA treatment. The findings suggest that down-regulation of p-CREB and acceleration of dynorphin synthesis in spinal cord. PAG and hypothalamus may be implicated in the cumulative effect of multiple 100 Hz EA treatment for opioid detoxification. (C) 2010 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30770690 ; 2009CB522003
项目资助者: National Natural Science Foundation ; National Basic Research Program of China
WOS记录号: WOS:000289707300013
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64068
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
3.Minist Publ Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Gui-Bin,Wu, Liu-Zhen,Yu, Peng,et al. Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated[J]. PEPTIDES,2011,32(4):713-721.
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