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学科主题基础医学
Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated
Wang, Gui-Bin; Wu, Liu-Zhen; Yu, Peng; Li, Yi-Jing; Ping, Xing-Jie; Cui, Cai-Lian
关键词Morphine dependence Withdrawal Electroacupuncture Preprodynorphin Preproenkephalin p-CREB
刊名PEPTIDES
2011-04-01
DOI10.1016/j.peptides.2010.12.006
32期:4页:713-721
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ELEMENT-BINDING PROTEIN ; BLOOD MONONUCLEAR-CELLS ; PERIAQUEDUCTAL GRAY ; OPIATE DEPENDENCE ; ENDOGENOUS ENKEPHALINS ; DIFFERENT FREQUENCIES ; PRODYNORPHIN GENE ; LOCUS-COERULEUS ; HEROIN-ADDICTS ; DYNORPHIN-A
英文摘要

Alleviating opiate withdrawal syndrome in addicts is a critical precondition to break away from drug and further to prevent reuse. Electroacupuncture (EA) was claimed to be effective for alleviating withdrawal syndrome, but the optimal protocol remained unclear. In the present study we found that (1) 100 Hz EA administered 12-24 h after the last morphine injection suppressed the withdrawal syndrome in rats, multiple sessions of EA were more effective than single session, with the after-effect lasting for at least 7 days. (2) A down-regulation of preprodynorphin (PPD) mRNA level was observed in spinal cord. PAG and hypothalamus 60 h after the last morph: ne injection, which could be reversed by multiple sessions, but cot a single session of EA. (3) Accompanied with the decrease of PPD mRNA level, there was an up-regulation of p-CREB in the three CNS regions, which was abolished by 100 Hz EA treatment. The findings suggest that down-regulation of p-CREB and acceleration of dynorphin synthesis in spinal cord. PAG and hypothalamus may be implicated in the cumulative effect of multiple 100 Hz EA treatment for opioid detoxification. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000289707300013
项目编号30770690 ; 2009CB522003
资助机构National Natural Science Foundation ; National Basic Research Program of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64068
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
3.Minist Publ Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Wang, Gui-Bin,Wu, Liu-Zhen,Yu, Peng,et al. Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated[J]. PEPTIDES,2011,32(4):713-721.
APA Wang, Gui-Bin,Wu, Liu-Zhen,Yu, Peng,Li, Yi-Jing,Ping, Xing-Jie,&Cui, Cai-Lian.(2011).Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated.PEPTIDES,32(4),713-721.
MLA Wang, Gui-Bin,et al."Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated".PEPTIDES 32.4(2011):713-721.
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