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学科主题: 临床医学
题名:
Association of genetic variants of vit D binding protein (DBP/GC) and of the enzyme catalyzing its 25-hydroxylation (DCYP2R1) and serum vit D in postmenopausal women
作者: Xu, Wen1; Sun, Jing1; Wang, Wenbo2; Wang, Xiran3; Jiang, Yan1; Huang, Wei4; Zheng, Xin5; Wang, Qiuping6; Ning, Zhiwei7; Pei, Yu8; Nie, Min1; Li, Mei1; Wang, Ou1; Xing, Xiaoping1; Yu, Wei9; Lin, Qiang9; Xu, Ling10; Xia, Weibo1
关键词: Association analysis ; BMD ; Bone turnover markers ; CYP2R1 ; GC ; SNP ; Vitamin D
刊名: HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
发表日期: 2014-07-01
卷: 13, 期:3, 页:345-352
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: GENOME-WIDE ASSOCIATION ; VITAMIN-D STATUS ; HEALTH
英文摘要:

OBJECTIVE: To determine if GC (group-specific component globulin) and CYP2R1 genetic variants have an association with serum 25-OHD3 levels, BMD or bone turnover markers in a population of Chinese postmenopausal women. DESIGN: We randomly selected 1494 postmenopausal women of the Han ethnic group from seven communities in Beijing. BMD was determined by dual energy X-ray absorptiometry; serum bone turnover markers and 25-OHD3 were measured by the automated Roche electrochemiluminescence system; genotypes of GC and CYP2R1 were detected by the TaqMan allelic discrimination assay. Multiple statistic methods were used to test the associations of SNP genotypes and vitamin D levels. RESULTS: In our sample, 89.6% women had vitamin D deficiency and another 9.8% had vitamin D insufficiency. The variants of rs2298849 (beta=0.105, P<0.001) in GC were significantly associated with serum 25-OHD3 levels. Allele G of rs2298849 might be protective for serum 25-OHD3 level. Among the haplotypes of rs222020-rs2298849, CG (beta=0.104, P=0.001) corresponded to increasing serum 25-OHD3 concentrations. CYP2R1 polymorphisms showed some significant association with serum beta-CTX and P1NP levels. CONCLUSIONS: We found that GC variants had a significant association with serum 25-OHD3 levels among postmenopausal women of the Han ethnic group in Beijing, while CYP2R1 variants were not found to be significant.

语种: 英语
所属项目编号: 81070687 ; 81170805 ; 2006BAI02B03 ; 2008ZX09312-016 ; 7121012 ; 2007-3029
项目资助者: National Natural Science Foundation of China ; National Science and Technology Pillar Program ; National Science and Technology Major Projects for "Major New Drugs Innovation and Development" ; Beijing Natural Science Foundation ; Scientific Research Foundation of Beijing Medical Development
WOS记录号: WOS:000342611200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64071
Appears in Collections:北京大学首钢医院_内分泌科_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Dept Endocrinol, Key Lab Endocrinol, Minist Hlth,Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
2.Peking Univ, Shougang Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
3.Gen Hosp Second Artillery Force, Dept Cadre Unit, Beijing, Peoples R China
4.BeiJing Haidian Hosp, Dept Endocrinol, Beijing, Peoples R China
5.China Rehabil Res Ctr, Dept Endocrinol, Beijing, Peoples R China
6.Beijing Liangxiang Hosp, Dept Endocrinol, Beijing, Peoples R China
7.Beijing Chaoyang Hosp, Dept Endocrinol, Beijing, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Endocrinol, Beijing, Peoples R China
9.Chinese Acad Med Sci, Dept Radiol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
10.Chinese Acad Med Sci, Dept Obstet & Gynaecol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China

Recommended Citation:
Xu, Wen,Sun, Jing,Wang, Wenbo,et al. Association of genetic variants of vit D binding protein (DBP/GC) and of the enzyme catalyzing its 25-hydroxylation (DCYP2R1) and serum vit D in postmenopausal women[J]. HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM,2014,13(3):345-352.
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