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学科主题临床医学
Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population
Liu, Maoxing1; Qu, Hong2; Bu, Zhaode3; Chen, Donglai4; Jiang, Beihai1; Cui, Ming1; Xing, Jiadi1; Yang, Hong1; Wang, Zaozao1; Di, Jiabo1; Chen, Lei1; Zhang, Chenghai1; Yao, Zhendan1; Zhang, Nan1; Tan, Fei1; Gu, Jin5; Li, Ziyu6; Su, Xiangqian1
刊名ANNALS OF SURGICAL ONCOLOGY
2015-11-01
DOI10.1245/s10434-015-4495-2
22期:12页:3881-3887
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]DISEASE-SPECIFIC SURVIVAL ; COLORECTAL-CANCER ; RESECTION ; HEPATECTOMY ; METASTASIS ; RECURRENCE ; CARCINOMA
英文摘要

Colon cancer nomogram designed by Memorial Sloan-Kettering Cancer Center (MSKCC) is an online prediction tool to predict overall survival for individual patient after curative resection. However, this model was never externally validated. We evaluated the accuracy of this nomogram in an independent external Chinese cohort.

Clinical data from 1005 patients who underwent primary curative-intent surgery at Peking University Cancer Hospital & Institute between 1996 and 2008 were used for external validation. Clinicopathologic characteristics and the performance of the MSKCC nomogram for prediction of overall survival were evaluated for 985 patients with complete data by using concordance index (C-index) and calibration plot.

The C-index for the MSKCC nomogram was 0.71 in the Chinese cohort, compared with 0.67 for American Joint Committee on Cancer (AJCC) stage (P < .0001). This suggests that the nomogram discriminates overall survival better than AJCC staging system. Calibration plot showed a good calibration of the nomogram in the validation cohort. Furthermore, the MSKCC nomogram prediction illustrated the heterogeneity for survival of Chinese patients within each AJCC stage.

The MSKCC nomogram for colon cancer provides more accurate survival predictions than the AJCC staging system when applied to an external Chinese cohort. The MSKCC nomogram improved individualized prediction of survival and may aid in more accurate patient counseling, selection of various treatment options, and follow-up scheduling.

语种英语
WOS记录号WOS:000362513100021
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64078
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_生化与分子生物学研究室
北京大学临床肿瘤学院_骨、微创外科
北京大学临床肿瘤学院_护理部
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Minimally Invas Gastrointestinal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
2.Peking Univ, State Key Lab Prot & Plant Gene Res, Coll Life Sci, Ctr Bioinformat, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg 2, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
4.Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA
5.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Colorectal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
6.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Maoxing,Qu, Hong,Bu, Zhaode,et al. Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population[J]. ANNALS OF SURGICAL ONCOLOGY,2015,22(12):3881-3887.
APA Liu, Maoxing.,Qu, Hong.,Bu, Zhaode.,Chen, Donglai.,Jiang, Beihai.,...&Su, Xiangqian.(2015).Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population.ANNALS OF SURGICAL ONCOLOGY,22(12),3881-3887.
MLA Liu, Maoxing,et al."Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population".ANNALS OF SURGICAL ONCOLOGY 22.12(2015):3881-3887.
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