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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population
作者: Liu, Maoxing1; Qu, Hong2; Bu, Zhaode3; Chen, Donglai4; Jiang, Beihai1; Cui, Ming1; Xing, Jiadi1; Yang, Hong1; Wang, Zaozao1; Di, Jiabo1; Chen, Lei1; Zhang, Chenghai1; Yao, Zhendan1; Zhang, Nan1; Tan, Fei1; Gu, Jin5; Li, Ziyu6; Su, Xiangqian1
刊名: ANNALS OF SURGICAL ONCOLOGY
发表日期: 2015-11-01
DOI: 10.1245/s10434-015-4495-2
卷: 22, 期:12, 页:3881-3887
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: DISEASE-SPECIFIC SURVIVAL ; COLORECTAL-CANCER ; RESECTION ; HEPATECTOMY ; METASTASIS ; RECURRENCE ; CARCINOMA
英文摘要:

Colon cancer nomogram designed by Memorial Sloan-Kettering Cancer Center (MSKCC) is an online prediction tool to predict overall survival for individual patient after curative resection. However, this model was never externally validated. We evaluated the accuracy of this nomogram in an independent external Chinese cohort.

Clinical data from 1005 patients who underwent primary curative-intent surgery at Peking University Cancer Hospital & Institute between 1996 and 2008 were used for external validation. Clinicopathologic characteristics and the performance of the MSKCC nomogram for prediction of overall survival were evaluated for 985 patients with complete data by using concordance index (C-index) and calibration plot.

The C-index for the MSKCC nomogram was 0.71 in the Chinese cohort, compared with 0.67 for American Joint Committee on Cancer (AJCC) stage (P < .0001). This suggests that the nomogram discriminates overall survival better than AJCC staging system. Calibration plot showed a good calibration of the nomogram in the validation cohort. Furthermore, the MSKCC nomogram prediction illustrated the heterogeneity for survival of Chinese patients within each AJCC stage.

The MSKCC nomogram for colon cancer provides more accurate survival predictions than the AJCC staging system when applied to an external Chinese cohort. The MSKCC nomogram improved individualized prediction of survival and may aid in more accurate patient counseling, selection of various treatment options, and follow-up scheduling.

语种: 英语
WOS记录号: WOS:000362513100021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64078
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Minimally Invas Gastrointestinal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
2.Peking Univ, State Key Lab Prot & Plant Gene Res, Coll Life Sci, Ctr Bioinformat, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg 2, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
4.Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA
5.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Colorectal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
6.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Maoxing,Qu, Hong,Bu, Zhaode,et al. Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population[J]. ANNALS OF SURGICAL ONCOLOGY,2015,22(12):3881-3887.
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