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学科主题: 临床医学
题名:
Association between arterial stiffness and peritoneal small solute transport rate
作者: Zhe, Xing-wei; Tian, Xin-kui; Chen, Wei; Guo, Li-juan; Gu, Yue; Chen, Hui-min; Tang, Li-jun; Wang, Tao
关键词: peritoneal transport rate ; arterial stiffness ; peritoneal dialysis
刊名: ARTIFICIAL ORGANS
发表日期: 2008-05-01
DOI: 10.1111/j.1525-1594.2008.00562.x
卷: 32, 期:5, 页:416-419
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Transplantation
研究领域[WOS]: Engineering ; Transplantation
关键词[WOS]: STAGE RENAL-DISEASE ; DIALYSIS PATIENTS ; TECHNIQUE SURVIVAL ; ATHEROSCLEROSIS ; MALNUTRITION ; HEMODIALYSIS ; INFLAMMATION ; MORTALITY ; FLUID ; MEMBRANE
英文摘要:

While cardiovascular disease accounts for 40-50% of the mortality in dialysis patients, and while a high peritoneal transport in continuous ambulatory peritoneal dialysis (CAPD) is an independent predictor of outcome, it is unclear if there are any links. Aortic stiffness has become established as a cardiovascular risk factor. We thus studied pulse wave velocity (PWV) in CAPD patients to explore the possible link between peritoneal small solute transport and aortic stiffness. CAPD patients (n = 76, 27 M/49 F) in our center were included in the present study. Aortic stiffness was assessed by brachial pulse pressure (PP) and carotid-femoral PWV. Patients′ peritoneal small solute transport rate was assessed by D/P(cr) at 4 h. Extracellular water over total body water (E/T ratio) was assessed by means of bioimpedance analysis. C-reactive protein was also measured. Carotid-femoral PWV was positively associated with patients′ age (r = 0.555; P < 0.01), time on peritoneal dialysis (r = 0.332; P < 0.01), diabetic status (r = 0.319; P < 0.01), D/P(cr) (r = 0.241; P < 0.05), PP (r = 0.475; P < 0.01), and E/T (r = 0.606; P < 0.01). In a multivariate regression analysis, carotid-femoral PWV was independently determined by E/T (P < 0.01), PP (P < 0.01), age (P < 0.01), and D/P(cr) (P < 0.05). D/P(cr), in addition to E/T, age, and PP, was an independent predictor of elevated carotid-femoral PWV in CAPD patients, suggesting that there might be a link between high aortic stiffness and increased peritoneal small solute transport rate.

语种: 英语
WOS记录号: WOS:000255699900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64080
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China

Recommended Citation:
Zhe, Xing-wei,Tian, Xin-kui,Chen, Wei,et al. Association between arterial stiffness and peritoneal small solute transport rate[J]. ARTIFICIAL ORGANS,2008,32(5):416-419.
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