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A significant reduction in hepatitis B virus infection among the children of Shandong Province, China: the effect of 15 years of universal infant hepatitis B vaccination
Zhang, Li2,3; Xu, Aiqiang3; Yan, Bingyu3; Song, Lizhi3; Li, Manshi3; Xiao, Zuokui3; Xu, Qing3; Li, Liming1
关键词Prevalence Universal infant hepatitis B vaccination Vaccination coverage
刊名INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
2010-06-01
DOI10.1016/j.ijid.2009.08.005
14期:6页:E483-E488
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]LONG-TERM IMMUNOGENICITY ; TAIWAN ; EFFICACY ; ANTIBODY ; PROGRAM
英文摘要

Objective: To evaluate the effect of the universal infant hepatitis B vaccination program on hepatitis B infection in China.

Methods: In 2006, a survey was conducted in Shandong Province, China, among children aged 1-14 years, 15 years after the introduction of universal infant hepatitis B vaccination. The subjects were selected by stratified, multi-stage sampling. Vaccination history was obtained by immunization certificate (when available) or parent recall. Hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and core antigen (anti-HBc) were detected by ELISA. Hepatitis B infection was defined as the presence of HBsAg and/or anti-HBc. The prevalence rates of HBsAg, anti-HBs and hepatitis B infection obtained in this survey were compared with the results of a survey conducted in 1992 (prior to universal vaccination).

Results: A total of 3738 children aged 1-14 years were included in the final analysis. A vaccination coverage rate of 93% was achieved in 2006. The prevalence rates of HBsAg and hepatitis B infection decreased from 8% and 46% in the 1992 survey to 1% and 4%, respectively, in the 2006 survey.

Conclusions: Universal hepatitis B vaccination in infants can result in a 90.47% reduction in hepatitis B infection in children aged 1-14 years. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000277726100005
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64082
专题北京大学公共卫生学院
作者单位1.Shandong Prov Ctr Dis Control & Prevent, Jinan, Peoples R China
2.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
3.Shandong Univ, Sch Publ Hlth, Jinan 250100, Peoples R China
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GB/T 7714
Zhang, Li,Xu, Aiqiang,Yan, Bingyu,et al. A significant reduction in hepatitis B virus infection among the children of Shandong Province, China: the effect of 15 years of universal infant hepatitis B vaccination[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2010,14(6):E483-E488.
APA Zhang, Li.,Xu, Aiqiang.,Yan, Bingyu.,Song, Lizhi.,Li, Manshi.,...&Li, Liming.(2010).A significant reduction in hepatitis B virus infection among the children of Shandong Province, China: the effect of 15 years of universal infant hepatitis B vaccination.INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,14(6),E483-E488.
MLA Zhang, Li,et al."A significant reduction in hepatitis B virus infection among the children of Shandong Province, China: the effect of 15 years of universal infant hepatitis B vaccination".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 14.6(2010):E483-E488.
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