IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Feasibility of noninvasive quantitative measurements of intrarenal R-2 ′ in humans using an asymmetric spin echo echo planar imaging sequence
Zhang, Xiaodong1; Zhang, Yudong2; Yang, Xuedong2; Wang, Xiaoying1,2; An, Hongyu3,4; Zhang, Jue1,5; Fang, Jing1,5
关键词asymmetric spin echo kidney R-2 &prime reproducibility furosemide
刊名NMR IN BIOMEDICINE
2013
DOI10.1002/nbm.2823
26期:1页:91-97
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
资助者Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities
研究领域[WOS]Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
关键词[WOS]CEREBRAL OXYGEN EXTRACTION ; MAGNETIC-RESONANCE ; BOLD-MRI ; BLOOD OXYGENATION ; RENAL OXYGENATION ; INITIAL-EXPERIENCE ; WATER-CONTENT ; 1.5 T ; BRAIN ; CONTRAST
英文摘要

The purpose of this study was to demonstrate the feasibility of an asymmetric spin echo (ASE) single-shot echo planar imaging (EPI) sequence for the noninvasive quantitative measurement of intrarenal R-2′ in humans within 20 s. The reproducibility of R-2′ measurements with the ASE-EPI sequence was assessed in nine healthy young subjects in repeated studies conducted over three consecutive days. Moreover, we also evaluated whether the ASE-EPI sequence-measured R-2′ reflected the intrarenal oxygenation changes induced by furosemide in another group of normal human subjects (n = 10). Different flow attenuation gradients (b = 0, 40 and 80 s/mm(2)) were utilized to examine the impact of the intravascular signal contribution on the estimation of intrarenal R-2′. In the absence of flow dephasing gradients (b = 0 s/mm(2)), the computed coefficient of variation (CV) of R-2′ was 21.31 +/- 4.52%, and the estimated R-2′ value decreased slightly, but not statistically significantly (p>0.05), after the administration of furosemide in the medullary region. However, CV of R-2′ was much smaller in the presence of flow dephasing gradients (9.68 +/- 3.58% with b = 40 s/mm(2) and 10.50 +/- 3.62% with b = 80 s/mm(2)). Moreover, a significant reduction in R-2′ in the renal medulla was obtained (p<0.05 for both b = 40 s/mm(2) and b = 80 s/mm(2)) after the administration of furosemide, reflecting an increase in oxygen tension in the medullary region. In addition, R-2′ measurements did not differ between the b = 40 s/mm(2) and b = 80 s/mm(2) scans, suggesting that small diffusion gradients were sufficient to minimize the intravascular signal contribution. In summary, we have demonstrated that renal R-2′ can be obtained rapidly using an ASE-EPI sequence. The measurement was highly reproducible and reflected the expected intrarenal oxygenation changes induced by furosemide. Copyright (C) 2012 John Wiley & Sons, Ltd.

语种英语
资助者Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities
WOS记录号WOS:000313886200011
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64097
Collection北京大学第一临床医学院_放射治疗科
作者单位1.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
2.Peking Univ, Dept Radiol, Hosp 1, Beijing 100871, Peoples R China
3.Univ N Carolina, Dept Radiol, Chapel Hill, NC USA
4.Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC USA
5.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xiaodong,Zhang, Yudong,Yang, Xuedong,et al. Feasibility of noninvasive quantitative measurements of intrarenal R-2 &prime; in humans using an asymmetric spin echo echo planar imaging sequence[J]. NMR IN BIOMEDICINE,2013,26(1):91-97.
APA Zhang, Xiaodong.,Zhang, Yudong.,Yang, Xuedong.,Wang, Xiaoying.,An, Hongyu.,...&Fang, Jing.(2013).Feasibility of noninvasive quantitative measurements of intrarenal R-2 ′ in humans using an asymmetric spin echo echo planar imaging sequence.NMR IN BIOMEDICINE,26(1),91-97.
MLA Zhang, Xiaodong,et al."Feasibility of noninvasive quantitative measurements of intrarenal R-2 ′ in humans using an asymmetric spin echo echo planar imaging sequence".NMR IN BIOMEDICINE 26.1(2013):91-97.
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