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Biomarkers for Lung Epithelium Injury in Occupational Hexavalent Chromium-Exposed Workers
Li, Ping1,4; Li, Yang1; Zhang, Ji2; Yu, Shan Fa3; Tong, Wei4; Hu, Xiao4; Jia, Guang1
刊名JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
2015-04-01
DOI10.1097/JOM.0000000000000436
57期:4页:E45-E50
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
资助者National Natural Science Foundations ; Ministry Education of China ; National Natural Science Foundations ; Ministry Education of China
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]CLARA CELL PROTEIN ; SERUM-LEVELS ; SECRETORY PROTEIN ; AIR-POLLUTION ; CC16 ; PNEUMOPROTEINS ; INDICATOR ; MARKERS ; SMOKE
英文摘要

Objective: To evaluate whether Club (Clara) cell protein (CC16) and surfactant-associated protein D (SP-D) can be used as biomarkers for lung injury caused by chromium exposure. Methods: The concentrations of chromium in the air (CrA), chromium in the blood (CrB), lung function, CC16, SP-D, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were detected in 91 chromium-exposed workers and 38 controls. Results: In chromium-exposed group, the levels of CrA, CrB, SP-D, TNF-alpha, and IL-6 were significantly higher, whereas forced expiratory volume in one second (FEV1), FEV1/FVC, maximal expiratory flow (MEF), maximum ventilation volume (MVV), CC16, and CC16/SP-D were lower. Negative correlations were shown between CC16, SP-D or CC16/SP-D, and CrB or inflammatory cytokines (TNF-alpha and IL-6). Positive relationships were shown between CC16 or CC16/SP-D with indicators of lung function. Tobacco smoking and chromium exposure had synergic effects on lung injury. Conclusions: CC16, as an immunosuppressive protein, and CC16/SP-D can be used as sensitive and noninvasive biomarkers for lung injury. Smoking should be banned in chromium workplaces.

语种英语
所属项目编号81073043 ; 81072281 ; 20120001110103
资助者National Natural Science Foundations ; Ministry Education of China ; National Natural Science Foundations ; Ministry Education of China
WOS记录号WOS:000352507700003
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64101
专题北京大学公共卫生学院
作者单位1.Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China
2.Inst Occupat Dis Prevent, Zhengzhou, Henan Province, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
4.Logist Univ Peoples Armed Police Force, Key Lab Occupat & Environm Hazards Prevent, Tianjin, Peoples R China
推荐引用方式
GB/T 7714
Li, Ping,Li, Yang,Zhang, Ji,et al. Biomarkers for Lung Epithelium Injury in Occupational Hexavalent Chromium-Exposed Workers[J]. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,2015,57(4):E45-E50.
APA Li, Ping.,Li, Yang.,Zhang, Ji.,Yu, Shan Fa.,Tong, Wei.,...&Jia, Guang.(2015).Biomarkers for Lung Epithelium Injury in Occupational Hexavalent Chromium-Exposed Workers.JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,57(4),E45-E50.
MLA Li, Ping,et al."Biomarkers for Lung Epithelium Injury in Occupational Hexavalent Chromium-Exposed Workers".JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 57.4(2015):E45-E50.
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