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学科主题临床医学
Role of Calcium-Sensing Receptor in Cardiac Injury of Hereditary Epileptic Rats
Li, Lei1; Chen, Fan2; Cao, Yong-gang2; Qi, Han-ping2; Huang, Wei2; Wang, Ye2; Jing, Shan3; Sun, Hong-li2
关键词Epilepsy Calcium-sensing receptor Tremor rat Cardiomyocyte apoptosis Myocardial fibrosis
刊名PHARMACOLOGY
2015
DOI10.1159/000369627
95期:1-2页:10-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Natural Science Foundation of the Heilongjiang Province of China ; Postdoctoral Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of the Heilongjiang Province of China ; Postdoctoral Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]INDUCED APOPTOSIS ; CORTICAL-NEURONS ; SUDDEN-DEATH ; CELL-DEATH ; KINASE ; REPERFUSION ; ISCHEMIA ; SEIZURES ; MODEL ; ARRHYTHMIAS
英文摘要

Background: It has been reported that epilepsy leads to cardiac injury, but the underlying mechanisms have not yet been elucidated. Studies indicated that the calcium-sensing receptor (CaSR) is involved in cardiomyocyte apoptosis. However, the role of CaSR in epilepsy-induced cardiac injury remains unclear. Objective: The aim of this study was to investigate the effects of CaSR on cardiac injury of hereditary epileptic rats. Methods: The tremor (TRM) rat was used as an epilepsy model. Apoptotic rate, collagen volume fraction, and the expression of CaSR, Bcl-2, Bax, caspase-3, extracellular signal-regulated protein kinase (ERK), c-Jun NH2-terminal protein kinase (JNK), p38 mitogen-activated protein kinase (MAPK), transforming growth factor-beta(1) (TGF-beta(1)), connective tissue growth factor (CTGF), collagen I and collagen III protein were analyzed. Results: The results showed that the CaSR protein was increased in TRM rat hearts. Cardiac apoptosis and fibrosis were also observed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and Masson′s trichrome staining, respectively. Further results demonstrated that the expression of Bax, caspase-3, P-JNK, P-p38, TGF-beta(1), CTGF, collagen I and collagen III protein were upregulated, whereas Bcl-2 and P-ERK were downregulated in TRM rat hearts. Moreover, these deleterious changes were further aggravated by GdCl3 and attenuated by NPS-2390. Conclusions: Our results suggest that CaSR promotes cardiac apoptosis and fibrosis in TRM rat through the induction of mitochondrial and MAPK pathways as well as the activation of TGF-beta(1) and CTGF. (C) 2015 S. Karger AG, Basel

语种英语
所属项目编号81072640 ; LC2012C19 ; 20080440902
资助者National Natural Science Foundation of China ; Natural Science Foundation of the Heilongjiang Province of China ; Postdoctoral Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of the Heilongjiang Province of China ; Postdoctoral Science Foundation of China
WOS记录号WOS:000351378300002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64105
专题北京大学第二临床医学院
作者单位1.Harbin Med Univ, Clin Coll 5, Dept Surg, Harbin, Peoples R China
2.Harbin Med Univ, Dept Pharmacol, Daqing, Peoples R China
3.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Li, Lei,Chen, Fan,Cao, Yong-gang,et al. Role of Calcium-Sensing Receptor in Cardiac Injury of Hereditary Epileptic Rats[J]. PHARMACOLOGY,2015,95(1-2):10-21.
APA Li, Lei.,Chen, Fan.,Cao, Yong-gang.,Qi, Han-ping.,Huang, Wei.,...&Sun, Hong-li.(2015).Role of Calcium-Sensing Receptor in Cardiac Injury of Hereditary Epileptic Rats.PHARMACOLOGY,95(1-2),10-21.
MLA Li, Lei,et al."Role of Calcium-Sensing Receptor in Cardiac Injury of Hereditary Epileptic Rats".PHARMACOLOGY 95.1-2(2015):10-21.
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