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学科主题: 临床医学
题名:
Role of Calcium-Sensing Receptor in Cardiac Injury of Hereditary Epileptic Rats
作者: Li, Lei1; Chen, Fan2; Cao, Yong-gang2; Qi, Han-ping2; Huang, Wei2; Wang, Ye2; Jing, Shan3; Sun, Hong-li2
关键词: Epilepsy ; Calcium-sensing receptor ; Tremor rat ; Cardiomyocyte apoptosis ; Myocardial fibrosis
刊名: PHARMACOLOGY
发表日期: 2015
DOI: 10.1159/000369627
卷: 95, 期:1-2, 页:10-21
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: INDUCED APOPTOSIS ; CORTICAL-NEURONS ; SUDDEN-DEATH ; CELL-DEATH ; KINASE ; REPERFUSION ; ISCHEMIA ; SEIZURES ; MODEL ; ARRHYTHMIAS
英文摘要:

Background: It has been reported that epilepsy leads to cardiac injury, but the underlying mechanisms have not yet been elucidated. Studies indicated that the calcium-sensing receptor (CaSR) is involved in cardiomyocyte apoptosis. However, the role of CaSR in epilepsy-induced cardiac injury remains unclear. Objective: The aim of this study was to investigate the effects of CaSR on cardiac injury of hereditary epileptic rats. Methods: The tremor (TRM) rat was used as an epilepsy model. Apoptotic rate, collagen volume fraction, and the expression of CaSR, Bcl-2, Bax, caspase-3, extracellular signal-regulated protein kinase (ERK), c-Jun NH2-terminal protein kinase (JNK), p38 mitogen-activated protein kinase (MAPK), transforming growth factor-beta(1) (TGF-beta(1)), connective tissue growth factor (CTGF), collagen I and collagen III protein were analyzed. Results: The results showed that the CaSR protein was increased in TRM rat hearts. Cardiac apoptosis and fibrosis were also observed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and Masson′s trichrome staining, respectively. Further results demonstrated that the expression of Bax, caspase-3, P-JNK, P-p38, TGF-beta(1), CTGF, collagen I and collagen III protein were upregulated, whereas Bcl-2 and P-ERK were downregulated in TRM rat hearts. Moreover, these deleterious changes were further aggravated by GdCl3 and attenuated by NPS-2390. Conclusions: Our results suggest that CaSR promotes cardiac apoptosis and fibrosis in TRM rat through the induction of mitochondrial and MAPK pathways as well as the activation of TGF-beta(1) and CTGF. (C) 2015 S. Karger AG, Basel

语种: 英语
所属项目编号: 81072640 ; LC2012C19 ; 20080440902
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of the Heilongjiang Province of China ; Postdoctoral Science Foundation of China
WOS记录号: WOS:000351378300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64105
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Harbin Med Univ, Clin Coll 5, Dept Surg, Harbin, Peoples R China
2.Harbin Med Univ, Dept Pharmacol, Daqing, Peoples R China
3.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Li, Lei,Chen, Fan,Cao, Yong-gang,et al. Role of Calcium-Sensing Receptor in Cardiac Injury of Hereditary Epileptic Rats[J]. PHARMACOLOGY,2015,95(1-2):10-21.
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