IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Chemoresponse to docetaxel correlates with expression of the survivin splicing variants in patients with gastric cancer
Meng, Hua1; Tanigawa, Nobuhiko2; Hao, Chun-Yi1; Dai, De-Jian3; Lu, Cai-De4,5; Ji, Jia-Fu1
关键词drug-response survivin splicing variants real time quantitative RT-PCR gastric cancer
刊名HEPATO-GASTROENTEROLOGY
2007-10-01
54期:79页:1934-1940
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]DRUG RESPONSE ASSAY ; PHASE-II ; APOPTOSIS ; HISTOCULTURE ; CISPLATIN ; CELLS ; TAXOL ; GENE ; RESISTANCE ; RP-56976
英文摘要

Background/Aims: Survivin, a potential predictive marker to chemotherapeutic drugs, reduces the susceptibility of tumor cells to proapoptotic stimuli, thereby promoting tumor cell survival during tumor treatment with anticancer agents. In the present study, we examined the correlation between drug-response and expression of survivin in gastric cancer.

Methodology: Drug-response was performed by histoculture drug-response assay (HDRA) in 42 patients with advanced gastric cancer. Survivin variants was studied by real-time RT-PCR at mRNA levels.

Results: In our data, twenty-one cases (50%) were sensitive to at least one of drugs tested in the HDRA and 80% (16/20) were positively confirmed clinically, with 100% sensitivity and 83.3% specificity. The diagnostic efficacy of the HDRA were calculated as the area under the receiver operating characteristic (AUC-ROC) curve and showed a value of 0.917. More importantly, significant statistical differences (p=0.012) in chemoresponse to docetaxel were revealed depending on the mRNA level of wild-type survivin.

Conclusions: These clinical data demonstrated, for the first time, that wild-type survivin is useful for evaluating the docetaxel-response in patients with gastric cancer. Moreover, the HDRA is an excellent clinical useful drug-response assay for patients to individualize their chemotherapy.

语种英语
WOS记录号WOS:000251892700009
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64106
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_肝胆胰外二科
作者单位1.Peking Univ, Beijing Canc Hosp, Dept Surg, Beijing Inst Canc Res,Sch Oncol, Beijing 100036, Peoples R China
2.Osaka Med Coll, Dept Gen & Gastroenterol Surg, Osaka, Japan
3.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200030, Peoples R China
4.Ningbo Univ, Sch Med, Affiliated Lihuili Hosp, Dept Gen Surg, Ningbo, Peoples R China
5.Ningbo Univ, Sch Med, Affiliated Lihuili Hosp, Dept Transplantat, Ningbo, Peoples R China
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Meng, Hua,Tanigawa, Nobuhiko,Hao, Chun-Yi,et al. Chemoresponse to docetaxel correlates with expression of the survivin splicing variants in patients with gastric cancer[J]. HEPATO-GASTROENTEROLOGY,2007,54(79):1934-1940.
APA Meng, Hua,Tanigawa, Nobuhiko,Hao, Chun-Yi,Dai, De-Jian,Lu, Cai-De,&Ji, Jia-Fu.(2007).Chemoresponse to docetaxel correlates with expression of the survivin splicing variants in patients with gastric cancer.HEPATO-GASTROENTEROLOGY,54(79),1934-1940.
MLA Meng, Hua,et al."Chemoresponse to docetaxel correlates with expression of the survivin splicing variants in patients with gastric cancer".HEPATO-GASTROENTEROLOGY 54.79(2007):1934-1940.
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