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Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients
Lei, Bin; Lv, Daojun; Zhou, Xuming; Zhang, Shoubo; Shu, Fangpeng; Ding, Yanqing; Zhang, Yuanyuan; Mao, Xiangming1
刊名UROLOGY
2015-05-01
DOI10.1016/j.urology.2015.02.011
85期:5页:1074-1078
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen ; National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen
研究领域[WOS]Urology & Nephrology
关键词[WOS]SPERM EXTRACTION ; INFERTILE MEN ; SPERMATOZOA ; PROLACTIN ; FRUCTOSE ; TESTIS ; MORPHOLOGY
英文摘要

OBJECTIVE To investigate the relationship between histopathologic patterns of testicular biopsy and biochemical semen and blood plasma parameters, including neutral a-glucosidase (NAG), fructose, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and prolactin (PRL) in patients with azoospermia.

MATERIALS AND METHODS A total of 471 azoospermic patients with definitive pathologic diagnosis were enrolled in this study. Six biochemical parameters, including 2 seminal (NAG and fructose) and 4 blood (FSH, LH, testosterone, and PRL) plasma markers, were analyzed.

RESULTS NAG, fructose, FSH, and LH levels were significantly higher in patients with Sertoli-cell-only (SCO) syndrome and severe hypospermatogenesis than in those with normal spermatogenesis or mild hypospermatogenesis (P < .05). In addition, NAG levels positively correlated with fructose amounts in azoospermic patients (P < .05); a significant correlation between FSH and LH levels was also observed in azoospermic patients. Furthermore, PRL levels were higher in SCO syndrome patients compared with subjects showing normal spermatogenesis and the levels positively correlated with NAG, FSH, and LH amounts. However, testosterone levels in SCO syndrome patients were significantly reduced compared with individuals having normal spermatogenesis.

CONCLUSION The levels of biochemical parameters in seminal (NAG and fructose) and blood (FSH, LH, testosterone, and PRL) plasma samples correlate with the histologic diagnosis in azoospermic patients, providing potential benefits in predicting the pathologic diagnosis of male infertility. (C) 2015 Elsevier Inc.

语种英语
所属项目编号81270743 ; 20140323125307
资助者National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen ; National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen
WOS记录号WOS:000353598600035
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64108
专题北京大学深圳医院_泌尿外科
作者单位1.Southern Med Univ, Dept Urol, Nanfang Hosp, Guangzhou 515000, Guangdong, Peoples R China
2.Guangzhou Med Univ, Assisted Reprod Ctr, Gen Hosp, Chinese Peoples Armed Police Forces, Guangzhou, Guangdong, Peoples R China
3.Southern Med Univ, Dept Pathol, Nanfang Hosp, Guangzhou 515000, Guangdong, Peoples R China
4.Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC USA
5.Peking Univ, Dept Urol, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Lei, Bin,Lv, Daojun,Zhou, Xuming,et al. Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients[J]. UROLOGY,2015,85(5):1074-1078.
APA Lei, Bin.,Lv, Daojun.,Zhou, Xuming.,Zhang, Shoubo.,Shu, Fangpeng.,...&Mao, Xiangming.(2015).Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients.UROLOGY,85(5),1074-1078.
MLA Lei, Bin,et al."Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients".UROLOGY 85.5(2015):1074-1078.
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