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学科主题: 临床医学
题名:
Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients
作者: Lei, Bin; Lv, Daojun; Zhou, Xuming; Zhang, Shoubo; Shu, Fangpeng; Ding, Yanqing; Zhang, Yuanyuan; Mao, Xiangming1
刊名: UROLOGY
发表日期: 2015-05-01
DOI: 10.1016/j.urology.2015.02.011
卷: 85, 期:5, 页:1074-1078
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SPERM EXTRACTION ; INFERTILE MEN ; SPERMATOZOA ; PROLACTIN ; FRUCTOSE ; TESTIS ; MORPHOLOGY
英文摘要:

OBJECTIVE To investigate the relationship between histopathologic patterns of testicular biopsy and biochemical semen and blood plasma parameters, including neutral a-glucosidase (NAG), fructose, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and prolactin (PRL) in patients with azoospermia.

MATERIALS AND METHODS A total of 471 azoospermic patients with definitive pathologic diagnosis were enrolled in this study. Six biochemical parameters, including 2 seminal (NAG and fructose) and 4 blood (FSH, LH, testosterone, and PRL) plasma markers, were analyzed.

RESULTS NAG, fructose, FSH, and LH levels were significantly higher in patients with Sertoli-cell-only (SCO) syndrome and severe hypospermatogenesis than in those with normal spermatogenesis or mild hypospermatogenesis (P < .05). In addition, NAG levels positively correlated with fructose amounts in azoospermic patients (P < .05); a significant correlation between FSH and LH levels was also observed in azoospermic patients. Furthermore, PRL levels were higher in SCO syndrome patients compared with subjects showing normal spermatogenesis and the levels positively correlated with NAG, FSH, and LH amounts. However, testosterone levels in SCO syndrome patients were significantly reduced compared with individuals having normal spermatogenesis.

CONCLUSION The levels of biochemical parameters in seminal (NAG and fructose) and blood (FSH, LH, testosterone, and PRL) plasma samples correlate with the histologic diagnosis in azoospermic patients, providing potential benefits in predicting the pathologic diagnosis of male infertility. (C) 2015 Elsevier Inc.

语种: 英语
所属项目编号: 81270743 ; 20140323125307
项目资助者: National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen
WOS记录号: WOS:000353598600035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64108
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Southern Med Univ, Dept Urol, Nanfang Hosp, Guangzhou 515000, Guangdong, Peoples R China
2.Guangzhou Med Univ, Assisted Reprod Ctr, Gen Hosp, Chinese Peoples Armed Police Forces, Guangzhou, Guangdong, Peoples R China
3.Southern Med Univ, Dept Pathol, Nanfang Hosp, Guangzhou 515000, Guangdong, Peoples R China
4.Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC USA
5.Peking Univ, Dept Urol, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Shenzhen, Peoples R China

Recommended Citation:
Lei, Bin,Lv, Daojun,Zhou, Xuming,et al. Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients[J]. UROLOGY,2015,85(5):1074-1078.
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