学科主题 | 临床医学 |
Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients | |
Lei, Bin; Lv, Daojun; Zhou, Xuming; Zhang, Shoubo; Shu, Fangpeng; Ding, Yanqing; Zhang, Yuanyuan; Mao, Xiangming1 | |
刊名 | UROLOGY
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2015-05-01 | |
DOI | 10.1016/j.urology.2015.02.011 |
卷 | 85期:5页:1074-1078 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Urology & Nephrology |
资助者 | National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen ; National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen |
研究领域[WOS] | Urology & Nephrology |
关键词[WOS] | SPERM EXTRACTION ; INFERTILE MEN ; SPERMATOZOA ; PROLACTIN ; FRUCTOSE ; TESTIS ; MORPHOLOGY |
英文摘要 | OBJECTIVE To investigate the relationship between histopathologic patterns of testicular biopsy and biochemical semen and blood plasma parameters, including neutral a-glucosidase (NAG), fructose, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and prolactin (PRL) in patients with azoospermia. MATERIALS AND METHODS A total of 471 azoospermic patients with definitive pathologic diagnosis were enrolled in this study. Six biochemical parameters, including 2 seminal (NAG and fructose) and 4 blood (FSH, LH, testosterone, and PRL) plasma markers, were analyzed. RESULTS NAG, fructose, FSH, and LH levels were significantly higher in patients with Sertoli-cell-only (SCO) syndrome and severe hypospermatogenesis than in those with normal spermatogenesis or mild hypospermatogenesis (P < .05). In addition, NAG levels positively correlated with fructose amounts in azoospermic patients (P < .05); a significant correlation between FSH and LH levels was also observed in azoospermic patients. Furthermore, PRL levels were higher in SCO syndrome patients compared with subjects showing normal spermatogenesis and the levels positively correlated with NAG, FSH, and LH amounts. However, testosterone levels in SCO syndrome patients were significantly reduced compared with individuals having normal spermatogenesis. CONCLUSION The levels of biochemical parameters in seminal (NAG and fructose) and blood (FSH, LH, testosterone, and PRL) plasma samples correlate with the histologic diagnosis in azoospermic patients, providing potential benefits in predicting the pathologic diagnosis of male infertility. (C) 2015 Elsevier Inc. |
语种 | 英语 |
所属项目编号 | 81270743 ; 20140323125307 |
资助者 | National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen ; National Natural Science Foundation of China ; Knowledge Innovation Program of Shenzhen |
WOS记录号 | WOS:000353598600035 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/64108 |
Collection | 北京大学深圳医院_泌尿外科 |
作者单位 | 1.Southern Med Univ, Dept Urol, Nanfang Hosp, Guangzhou 515000, Guangdong, Peoples R China 2.Guangzhou Med Univ, Assisted Reprod Ctr, Gen Hosp, Chinese Peoples Armed Police Forces, Guangzhou, Guangdong, Peoples R China 3.Southern Med Univ, Dept Pathol, Nanfang Hosp, Guangzhou 515000, Guangdong, Peoples R China 4.Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC USA 5.Peking Univ, Dept Urol, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Shenzhen, Peoples R China |
Recommended Citation GB/T 7714 | Lei, Bin,Lv, Daojun,Zhou, Xuming,et al. Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients[J]. UROLOGY,2015,85(5):1074-1078. |
APA | Lei, Bin.,Lv, Daojun.,Zhou, Xuming.,Zhang, Shoubo.,Shu, Fangpeng.,...&Mao, Xiangming.(2015).Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients.UROLOGY,85(5),1074-1078. |
MLA | Lei, Bin,et al."Biochemical Hormone Parameters in Seminal and Blood Plasma Samples Correlate With Histopathologic Properties of Testicular Biopsy in Azoospermic Patients".UROLOGY 85.5(2015):1074-1078. |
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