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学科主题: 临床医学
题名:
Surface-enhanced Raman spectroscopy for simultaneous sensitive detection of multiple microRNAs in lung cancer cells
作者: Ye, Li-Ping1; Hu, Juan1; Liang, Li2; Zhang, Chun-yang1
刊名: CHEMICAL COMMUNICATIONS
发表日期: 2014
DOI: 10.1039/c4cc05598e
卷: 50, 期:80, 页:11883-11886
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: ROLLING-CIRCLE AMPLIFICATION ; ISOTHERMAL AMPLIFICATION ; ULTRASENSITIVE DETECTION ; MIRNA DETECTION ; NUCLEIC-ACIDS ; DNA DETECTION ; SERS ; PROTEIN ; SCATTERING ; OLIGONUCLEOTIDES
英文摘要:

We develop circular exponential amplification reaction (EXPAR)-based surface-enhanced Raman spectroscopy (SERS) for simultaneous sensitive detection of multiple microRNAs in non-small cell lung cancer cells. This method possesses distinct advantages of excellent selectivity and high sensitivity with a detection limit of as low as 0.5 fM, which has improved by as much as 6 orders of magnitude as compared with the previously reported SERS-based direct assay.

语种: 英语
所属项目编号: 21325523 ; 21205128 ; 433 ; 201002009 ; 2013-BYSY-CAS-007
项目资助者: National Natural Science Foundation of China ; Award for the Hundred Talent Program of the Chinese Academy of Sciences ; Fund for Shenzhen Engineering Laboratory of Single-molecule Detection and Instrument Development ; State Ministry of Health of China ; Peking University Third Hospital
WOS记录号: WOS:000342201700023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64112
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Single Mol Detect & Imaging Lab, Guangzhou 518055, Guangdong, Peoples R China
2.Peking Univ, Hosp 3, Dept Tumor Chemotherapy & Radiat Sickness, Beijing 100191, Peoples R China

Recommended Citation:
Ye, Li-Ping,Hu, Juan,Liang, Li,et al. Surface-enhanced Raman spectroscopy for simultaneous sensitive detection of multiple microRNAs in lung cancer cells[J]. CHEMICAL COMMUNICATIONS,2014,50(80):11883-11886.
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