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学科主题: 临床医学
题名:
Safety of Recombinant Human Thrombopoietin in Adults after Related Do !E poietic Stem Cell Transplantation A Pilot Study
作者: Liu, Dai-Hong; Huang, Xiao-Jun; Liu, Kai-Yan; Xu, Lan-Ping; Chen, Yu-Hong; Wang, Yu; Han, Wei; Chen, Huan
刊名: CLINICAL DRUG INVESTIGATION
发表日期: 2011
卷: 31, 期:2, 页:135-141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; HUMAN MEGAKARYOCYTE GROWTH ; PHASE-I TRIAL ; HEMATOLOGIC MALIGNANCIES ; ADVANCED CANCER ; VITRO ; THROMBOCYTOPENIA ; CHEMOTHERAPY ; DEPLETION ; DISEASE
英文摘要:

Background and Objective: Delayed recovery of platelets can be found in recipients of related donor haploidentical haematopoietic stem cell transplantation (HSCT). The objective of this study was to evaluate the safety of recombinant human thrombopoietin (rhTPO) administration prior to engraftment in patients who received related donor haploidentical HSCT.

Methods: Nineteen patients with haematological malignancies received rhTPO prior to platelet engraftment after related donor haploidentical HSCT. Safety and tolerability levels together with the influence of rhTPO on the outcome of transplantation were evaluated.

Results: Slight elevations in ALT and/or AST were observed in five patients; in two other patients, bilirubin levels increased slightly. No significant changes in routine examination findings and no allergic reactions were observed during the study period. Eighteen patients achieved platelet engraftment at a median of 16 (range 11-34) days. The cumulative +/- SD incidence of acute graft-versus-host disease (GVHD) grade 1-4 at +100 days was 68.4 +/- 10.7%, and that of chronic GVHD at 3 years was 24.7 +/- 10.7%. Nine (47.4%) patients survived free of relapse, with a median follow-up of 1631 (1550-1734) days after transplantation.

Conclusion: Early administration of rhTPO prior to engraftment was safe and well tolerated in patients receiving related donor haploidentical HSCT.

语种: 英语
WOS记录号: WOS:000286027500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64116
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Dai-Hong,Huang, Xiao-Jun,Liu, Kai-Yan,et al. Safety of Recombinant Human Thrombopoietin in Adults after Related Donor Haploidentical Haematopoietic Stem Cell Transplantation A Pilot Study[J]. CLINICAL DRUG INVESTIGATION,2011,31(2):135-141.
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