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学科主题: 临床医学
题名:
HBV recurrence lowered by lamivudine/HBIG combination therapy in liver transplant patients: ten-year experience
作者: Yuan, Chun-Hui; Xiu, Dian-Rong; Jiang, Bin; Li, Zhi-Fei; Li, Lei; Song, Shi-Bing; Zhang, Tong-Lin
关键词: hepatitis B virus ; recurrence ; lamivudine ; hepatitis B immunoglobulin ; liver transplantation
刊名: HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
发表日期: 2013-04-15
DOI: 10.1016/S1499-3872(13)60024-7
卷: 12, 期:2, 页:149-153
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HEPATITIS-B-VIRUS ; SINGLE-CENTER EXPERIENCE ; INFECTION ; PREVENTION ; IMMUNOGLOBULIN ; PROPHYLAXIS ; OUTCOMES ; IMMUNOPROPHYLAXIS ; RESISTANCE ; EFFICACY
英文摘要:

BACKGROUND: Lamivudine and hepatitis B immunoglobulin (HBIG) are widely used to treat patients with hepatitis B recurrence after liver transplantation. However, the outcomes are inconclusive. The present study was undertaken to evaluate the effect of combined therapy on patients with hepatitis B recurrence after liver transplantation.

METHODS: Twenty-two patients with hepatitis B recurrence after liver transplantation from August 2000 to October 2011 were enrolled in this study. Of these patients, 16 received lamivudine plus HBIG (combination therapy group) and 6 were treated with lamivudine alone (lamivudine-treated group). The clinical features were matched in the two groups. HBV recurrence parameters, HBsAg clearance rate, patient survival rate, and survival time were compared.

RESULTS: The average time of follow-up was 47.2 months (range 13-99). Significant difference was noted in the HBsAg clearance rate in the lamivudine-treated and combination therapy groups (50% vs 93.8%, P<0.05). There was no significant difference in the time of HBV recurrence, patient survival rate and survival time between lamivudine-treated and combination therapy groups (P>0.05).

CONCLUSION: Compared with lamivudine monotherapy, combination therapy significantly increased the HBsAg clearance rate in patients with HBV recurrence after liver transplantation. (Hepatobiliary Pancreat Dis Int 2013;12:149-153)

语种: 英语
所属项目编号: 30872556
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000317438900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64119
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China

Recommended Citation:
Yuan, Chun-Hui,Xiu, Dian-Rong,Jiang, Bin,et al. HBV recurrence lowered by lamivudine/HBIG combination therapy in liver transplant patients: ten-year experience[J]. HEPATOBILIARY &amp; PANCREATIC DISEASES INTERNATIONAL,2013,12(2):149-153.
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