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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T- cell depletion: superior outcomes compared with chemotherapy alone and an analysis of prognostic factors
作者: Yan, Chen-Hua; Wang, Jing-Zhi; Liu, Dai-Hong; Xu, Lan-Ping; Chen, Huan; Liu, Kai-Yan; Huang, Xiao-Jun
关键词: allogeneic hematopoietic stem cell transplantation ; haploidentical ; relapse ; acute leukemia ; donor lymphocyte infusion ; chemotherapy
刊名: EUROPEAN JOURNAL OF HAEMATOLOGY
发表日期: 2013-10-01
DOI: 10.1111/ejh.12168
卷: 91, 期:4, 页:304-314
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; VERSUS-HOST-DISEASE ; LEUKOCYTE INFUSIONS ; PERIPHERAL-BLOOD ; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE ; PROSPECTIVE TRIAL ; WORKING PARTY ; RISK-FACTORS ; CSF
英文摘要:

We retrospectively compared the antileukemic effects of chemotherapy alone and chemotherapy followed by modified donor lymphocyte infusion (DLI) in 82 patients with relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T-cell depletion. We also investigated prognostic factors in patients receiving chemotherapy followed by modified DLI. Thirty-two patients received chemotherapy alone, and the remaining 50 patients received chemotherapy followed by modified DLI. In patients receiving chemotherapy followed by modified DLI, complete remission rate was significantly higher (64.0% vs. 12.5%, P=0.000), the incidence of relapse was significantly lower (50.0% vs. 100.0%, P=0.000), and disease-free survival was significantly improved (36.0% vs. 0.0%, P=0.000) compared with patients receiving chemotherapy alone. Multivariate analysis demonstrated that patients with chronic graft-versus-host disease (GVHD) after intervention (P=0.000) and patients receiving chemotherapy followed by modified DLI (P=0.037) were associated with a lower relapse rate. Furthermore, in patients receiving chemotherapy followed by modified DLI, multivariate analysis demonstrated that chronic GVHD after modified DLI (P=0.039) and duration of minimal residual disease (MRD) (-) 4months after modified DLI (P=0.001) were associated with a lower relapse rate. Our study is the first to suggest that chemotherapy followed by modified DLI is associated with stronger antileukemic effects and better survival in relapsed acute leukemia after haploidentical HSCT without in vitro T-cell depletion. Furthermore, our study suggests that lack of chronic GVHD and duration of MRD (-) <4months after modified DLI are associated with higher relapse rates in patients receiving chemotherapy followed by modified DLI.

语种: 英语
所属项目编号: 30971292
项目资助者: National Key Clinical Discipline Projects by the Ministry of Health of China ; Key Clinical Program of Hospitals affiliated to the Ministry of Health of China ; National Natural Science Foundation of China
WOS记录号: WOS:000325035000003
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64122
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

Recommended Citation:
Yan, Chen-Hua,Wang, Jing-Zhi,Liu, Dai-Hong,et al. Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T- cell depletion: superior outcomes compared with chemotherapy alone and an analysis of prognostic factors[J]. EUROPEAN JOURNAL OF HAEMATOLOGY,2013,91(4):304-314.
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