北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 消化内科  > 期刊论文
学科主题: 临床医学
题名:
XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells
作者: Qiao, Liang; Gu, Qing; Dai, Yun2; Shen, Zan1; Liu, Xinyuan3; Qi, Rong3; Ma, Juan; Zou, Bing; Lia, Zesong; Lan, Hui Y.; Wong, Benjamin C. Y.
关键词: XAF1 ; angiogenesis ; endothelial cells ; apoptosis
刊名: TUMOR BIOLOGY
发表日期: 2008
DOI: 10.1159/000137831
卷: 29, 期:2, 页:122-129
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GROWTH-FACTOR ; C-MYC ; SURVIVAL FACTOR ; EXPRESSION ; ANGIOPOIETIN-1 ; ANTAGONIST ; APOPTOSIS ; MECHANISMS ; RECEPTOR ; TIE2
英文摘要:

Objectives: XIAP-associated factor 1 (XAF1) is a tumor suppressor gene, but its role in angiogenesis is unknown. We investigated whether XAF1 has any antiangiogenesis effect. Methods: MS1 (a mouse endothelial cell line) was infected with an adenoviral vector ZD55-XAF1. Controls were uninfected or infected with ZD55-EGFP. Wound healing assay and tube formation assay were used to assess angiogenesis. Cell proliferation was detected by WST-1 assay, and apoptosis was detected by TUNEL and APOPercentage (TM) assays. Results: ZD55-XAF1 significantly upregulated XAF1, which was associated with decreased cell proliferation, migration and tube formation of MS1 cells. Ectopic overexpression of XAF1 induced apoptosis in MS1 and also sensitized cells to 5-fluorouracil-induced apoptosis. A significant decrease in the expression of Tie-1, Ang-1, Ang-2 and c-Myc was observed. Conclusions: Our data suggest that XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect. Copyright (C) 2008 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000257903500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64123
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China

Recommended Citation:
Qiao, Liang,Gu, Qing,Dai, Yun,et al. XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells[J]. TUMOR BIOLOGY,2008,29(2):122-129.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qiao, Liang]'s Articles
[Gu, Qing]'s Articles
[Dai, Yun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qiao, Liang]‘s Articles
[Gu, Qing]‘s Articles
[Dai, Yun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace