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学科主题临床医学
XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells
Qiao, Liang; Gu, Qing; Dai, Yun2; Shen, Zan1; Liu, Xinyuan3; Qi, Rong3; Ma, Juan; Zou, Bing; Lia, Zesong; Lan, Hui Y.; Wong, Benjamin C. Y.
关键词XAF1 angiogenesis endothelial cells apoptosis
刊名TUMOR BIOLOGY
2008
DOI10.1159/000137831
29期:2页:122-129
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GROWTH-FACTOR ; C-MYC ; SURVIVAL FACTOR ; EXPRESSION ; ANGIOPOIETIN-1 ; ANTAGONIST ; APOPTOSIS ; MECHANISMS ; RECEPTOR ; TIE2
英文摘要

Objectives: XIAP-associated factor 1 (XAF1) is a tumor suppressor gene, but its role in angiogenesis is unknown. We investigated whether XAF1 has any antiangiogenesis effect. Methods: MS1 (a mouse endothelial cell line) was infected with an adenoviral vector ZD55-XAF1. Controls were uninfected or infected with ZD55-EGFP. Wound healing assay and tube formation assay were used to assess angiogenesis. Cell proliferation was detected by WST-1 assay, and apoptosis was detected by TUNEL and APOPercentage (TM) assays. Results: ZD55-XAF1 significantly upregulated XAF1, which was associated with decreased cell proliferation, migration and tube formation of MS1 cells. Ectopic overexpression of XAF1 induced apoptosis in MS1 and also sensitized cells to 5-fluorouracil-induced apoptosis. A significant decrease in the expression of Tie-1, Ang-1, Ang-2 and c-Myc was observed. Conclusions: Our data suggest that XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect. Copyright (C) 2008 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000257903500007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64123
专题北京大学第一临床医学院_消化科
作者单位1.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China
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GB/T 7714
Qiao, Liang,Gu, Qing,Dai, Yun,et al. XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells[J]. TUMOR BIOLOGY,2008,29(2):122-129.
APA Qiao, Liang.,Gu, Qing.,Dai, Yun.,Shen, Zan.,Liu, Xinyuan.,...&Wong, Benjamin C. Y..(2008).XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells.TUMOR BIOLOGY,29(2),122-129.
MLA Qiao, Liang,et al."XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells".TUMOR BIOLOGY 29.2(2008):122-129.
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