学科主题 | 临床医学 |
XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells | |
Qiao, Liang; Gu, Qing; Dai, Yun2; Shen, Zan1; Liu, Xinyuan3; Qi, Rong3; Ma, Juan; Zou, Bing; Lia, Zesong; Lan, Hui Y.; Wong, Benjamin C. Y. | |
关键词 | XAF1 angiogenesis endothelial cells apoptosis |
刊名 | TUMOR BIOLOGY
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2008 | |
DOI | 10.1159/000137831 |
卷 | 29期:2页:122-129 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Oncology |
研究领域[WOS] | Oncology |
关键词[WOS] | GROWTH-FACTOR ; C-MYC ; SURVIVAL FACTOR ; EXPRESSION ; ANGIOPOIETIN-1 ; ANTAGONIST ; APOPTOSIS ; MECHANISMS ; RECEPTOR ; TIE2 |
英文摘要 | Objectives: XIAP-associated factor 1 (XAF1) is a tumor suppressor gene, but its role in angiogenesis is unknown. We investigated whether XAF1 has any antiangiogenesis effect. Methods: MS1 (a mouse endothelial cell line) was infected with an adenoviral vector ZD55-XAF1. Controls were uninfected or infected with ZD55-EGFP. Wound healing assay and tube formation assay were used to assess angiogenesis. Cell proliferation was detected by WST-1 assay, and apoptosis was detected by TUNEL and APOPercentage (TM) assays. Results: ZD55-XAF1 significantly upregulated XAF1, which was associated with decreased cell proliferation, migration and tube formation of MS1 cells. Ectopic overexpression of XAF1 induced apoptosis in MS1 and also sensitized cells to 5-fluorouracil-induced apoptosis. A significant decrease in the expression of Tie-1, Ang-1, Ang-2 and c-Myc was observed. Conclusions: Our data suggest that XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect. Copyright (C) 2008 S. Karger AG, Basel. |
语种 | 英语 |
WOS记录号 | WOS:000257903500007 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/64123 |
Collection | 北京大学第一临床医学院_消化科 |
作者单位 | 1.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China 2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China |
Recommended Citation GB/T 7714 | Qiao, Liang,Gu, Qing,Dai, Yun,et al. XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells[J]. TUMOR BIOLOGY,2008,29(2):122-129. |
APA | Qiao, Liang.,Gu, Qing.,Dai, Yun.,Shen, Zan.,Liu, Xinyuan.,...&Wong, Benjamin C. Y..(2008).XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells.TUMOR BIOLOGY,29(2),122-129. |
MLA | Qiao, Liang,et al."XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells".TUMOR BIOLOGY 29.2(2008):122-129. |
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