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Discrimination of metastatic lymph nodes in patients with gastric carcinoma using diffusion-weighted imaging
Cheng, Jin1; Wang, Yi1; Deng, Jie2; McCarthy, Robert J.3; Wang, Gongwei4; Wang, He5; Ye, Yingjiang6
关键词diffusion-weighted imaging gastric carcinoma lymph nodes metastases
刊名JOURNAL OF MAGNETIC RESONANCE IMAGING
2013-06-01
DOI10.1002/jmri.23925
37期:6页:1436-1444
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; CERVICAL LYMPHADENOPATHY ; DIAGNOSTIC-ACCURACY ; NECK-CANCER ; HELICAL CT ; HEAD ; DISSECTION ; MRI ; ADENOCARCINOMA ; APPRAISAL
英文摘要

Purpose: To determine the accuracy of diffusion-weighted imaging (DWI) in discrimination of metastatic lymph nodes (LNs) in gastric carcinoma with rigorous histopathological correlation. Materials and Methods: With Institutional Review Board (IRB) approval, 28 patients with gastric carcinoma underwent magnetic resonance imaging (MRI) and DWI before surgery. LNs were resected at surgery and thereafter submitted for histopathological analyses. All histopathologically identified LNs (5 mm) that exactly matched the location and size of nodes on MRI/DWI were submitted to lesion-by-lesion analyses. Short-axis diameter, border irregularity, enhanced patterns, and apparent diffusion coefficient (ADC) values of each LN were recorded. Each measurement was compared between metastatic and benign LNs, confirmed by nodal histopathology. A receiver operating characteristic (ROC) curve was generated to evaluate the capability of morphological and ADC measurements in distinguishing metastatic lymph nodes. Results: The median ADC value of metastatic nodes was significantly lower (1.28 x 103 mm2/sec; interquartile range, 1.201.31) than that of benign (1.55; 1.471.73) nodes (P < 0.001). DWI showed greater diagnostic accuracy in determining metastatic nodes (AUC = 0.857) than the combined morphological measurements of short-axis, border irregularity, and enhanced patterns (AUC = 0.746, P = 0.03). Adding ADC values to the combined morphologic criteria demonstrated the greatest predictive power (AUC = 0.889). Conclusion: DWI may provide great potential in effective discrimination of metastatic LNs in gastric carcinoma. J. Magn. Reson. Imaging 2013;37:14361444. (c) 2012 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000319420000018
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64125
专题北京大学第二临床医学院_放射科
北京大学第一临床医学院_医学影像科
作者单位1.Childrens Mem Hosp, Dept Radiol, Chicago, IL 60614 USA
2.GE Healthcare, Maxdo Ctr, Shanghai, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China
4.Northwestern Univ, NW Mem Hosp, Dept Anesthesiol, Chicago, IL 60611 USA
5.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100044, Peoples R China
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Cheng, Jin,Wang, Yi,Deng, Jie,et al. Discrimination of metastatic lymph nodes in patients with gastric carcinoma using diffusion-weighted imaging[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2013,37(6):1436-1444.
APA Cheng, Jin.,Wang, Yi.,Deng, Jie.,McCarthy, Robert J..,Wang, Gongwei.,...&Ye, Yingjiang.(2013).Discrimination of metastatic lymph nodes in patients with gastric carcinoma using diffusion-weighted imaging.JOURNAL OF MAGNETIC RESONANCE IMAGING,37(6),1436-1444.
MLA Cheng, Jin,et al."Discrimination of metastatic lymph nodes in patients with gastric carcinoma using diffusion-weighted imaging".JOURNAL OF MAGNETIC RESONANCE IMAGING 37.6(2013):1436-1444.
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