IR@PKUHSC  > 北京大学第一临床医学院  > 血液内科
学科主题临床医学
Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
Li, Jianxin1,2; Lai, Xin2; Yan, Cunliang2; Xu, Anping2; Nie, Liping2; Zhou, Yu2; Liao, Chaoyu2; Ren, Hanyun1
关键词activated partial thromboplastin time blood coagulation factor developmental hemostasis lupus anticoagulants
刊名CLINICAL CHEMISTRY AND LABORATORY MEDICINE
2009-12-01
DOI10.1515/CCLM.2009.339
47期:12页:1531-1537
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
资助者Scientific and Technologic Program of Healthy Bureau in Shenzhen City, China ; Scientific and Technologic Program of Healthy Bureau in Shenzhen City, China
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]FACTOR-V-LEIDEN ; TRANSIENT LUPUS ANTICOAGULANT ; HUMAN COAGULATION SYSTEM ; DEEP VENOUS THROMBOSIS ; FACTOR-XII ACTIVITY ; ANTIPHOSPHOLIPID ANTIBODIES ; PULMONARY THROMBOEMBOLISM ; PEDIATRIC-PATIENTS ; HAGEMAN-FACTOR ; HEMOSTATIC SYSTEM
英文摘要

Background: The concept of developmental hemostasis has been universally accepted. Physiological reference ranges for coagulation tests are available for infants and children of different ages. However, on Oriental children they are rare.

Methods: Results of preoperative activated partial thromboplastin time (APTT) in neonates, infants, children aged 1-18 years and adults with minor elective surgery in a university affiliated hospital were reviewed retrospectively. Plasma activity of factors VIII, IX, XI, XII (FVIII: C, FIX: C, FXI: C, FXII: C) and lupus anticoagulants (LAC) in 47 children with prolonged APTT and 34 adult controls were measured to investigate the causes of prolongation.

Results: Compared with adults, APTT values were prolonged significantly and were age-dependent in children, especially in neonates and infants aged 1-6 months. Mean values for FXII: C and FIX: C in children with prolonged APTT values were significantly lower than those in adults (p<0.001). Prolonged APTT values correlated negatively with FXII: C and FIX: C, and weakly with the LAC Screen ratio (LAC-SR) (r(0.01)=-0.808, -0.705 and 0.372, p=0.000, 0.000 and 0.001, respectively). There was weak negative correlation between FXII: C and LAC-SR (r(0.01)=-0.277, ps0.012). No significant correlation was seen between prolonged APTT values and FVIII: C or FXI: C.

Conclusions: APTT values change dynamically with age during childhood and display a distinct pattern of evolution in children. Lower values of FXII: C and FIX: C, and presence of LAC contribute to the prolongation of APTT values in Chinese children. Clin Chem Lab Med 2009;47:1531-7.

语种英语
所属项目编号200609
资助者Scientific and Technologic Program of Healthy Bureau in Shenzhen City, China ; Scientific and Technologic Program of Healthy Bureau in Shenzhen City, China
WOS记录号WOS:000272257900013
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64132
专题北京大学第一临床医学院_血液内科
作者单位1.Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Lab Med, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Li, Jianxin,Lai, Xin,Yan, Cunliang,et al. Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2009,47(12):1531-1537.
APA Li, Jianxin.,Lai, Xin.,Yan, Cunliang.,Xu, Anping.,Nie, Liping.,...&Ren, Hanyun.(2009).Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children.CLINICAL CHEMISTRY AND LABORATORY MEDICINE,47(12),1531-1537.
MLA Li, Jianxin,et al."Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children".CLINICAL CHEMISTRY AND LABORATORY MEDICINE 47.12(2009):1531-1537.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Jianxin]的文章
[Lai, Xin]的文章
[Yan, Cunliang]的文章
百度学术
百度学术中相似的文章
[Li, Jianxin]的文章
[Lai, Xin]的文章
[Yan, Cunliang]的文章
必应学术
必应学术中相似的文章
[Li, Jianxin]的文章
[Lai, Xin]的文章
[Yan, Cunliang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。