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学科主题: 临床医学
题名:
Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
作者: Li, Jianxin1,2; Lai, Xin2; Yan, Cunliang2; Xu, Anping2; Nie, Liping2; Zhou, Yu2; Liao, Chaoyu2; Ren, Hanyun1
关键词: activated partial thromboplastin time ; blood coagulation factor ; developmental hemostasis ; lupus anticoagulants
刊名: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
发表日期: 2009-12-01
DOI: 10.1515/CCLM.2009.339
卷: 47, 期:12, 页:1531-1537
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: FACTOR-V-LEIDEN ; TRANSIENT LUPUS ANTICOAGULANT ; HUMAN COAGULATION SYSTEM ; DEEP VENOUS THROMBOSIS ; FACTOR-XII ACTIVITY ; ANTIPHOSPHOLIPID ANTIBODIES ; PULMONARY THROMBOEMBOLISM ; PEDIATRIC-PATIENTS ; HAGEMAN-FACTOR ; HEMOSTATIC SYSTEM
英文摘要:

Background: The concept of developmental hemostasis has been universally accepted. Physiological reference ranges for coagulation tests are available for infants and children of different ages. However, on Oriental children they are rare.

Methods: Results of preoperative activated partial thromboplastin time (APTT) in neonates, infants, children aged 1-18 years and adults with minor elective surgery in a university affiliated hospital were reviewed retrospectively. Plasma activity of factors VIII, IX, XI, XII (FVIII: C, FIX: C, FXI: C, FXII: C) and lupus anticoagulants (LAC) in 47 children with prolonged APTT and 34 adult controls were measured to investigate the causes of prolongation.

Results: Compared with adults, APTT values were prolonged significantly and were age-dependent in children, especially in neonates and infants aged 1-6 months. Mean values for FXII: C and FIX: C in children with prolonged APTT values were significantly lower than those in adults (p<0.001). Prolonged APTT values correlated negatively with FXII: C and FIX: C, and weakly with the LAC Screen ratio (LAC-SR) (r(0.01)=-0.808, -0.705 and 0.372, p=0.000, 0.000 and 0.001, respectively). There was weak negative correlation between FXII: C and LAC-SR (r(0.01)=-0.277, ps0.012). No significant correlation was seen between prolonged APTT values and FVIII: C or FXI: C.

Conclusions: APTT values change dynamically with age during childhood and display a distinct pattern of evolution in children. Lower values of FXII: C and FIX: C, and presence of LAC contribute to the prolongation of APTT values in Chinese children. Clin Chem Lab Med 2009;47:1531-7.

语种: 英语
所属项目编号: 200609
项目资助者: Scientific and Technologic Program of Healthy Bureau in Shenzhen City, China
WOS记录号: WOS:000272257900013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64132
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Lab Med, Shenzhen, Peoples R China

Recommended Citation:
Li, Jianxin,Lai, Xin,Yan, Cunliang,et al. Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2009,47(12):1531-1537.
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