IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Functional analysis of core binding factor a1 and its relationship with related genes expressed by human periodontal ligament cells exposed to mechanical stress
Yang, Ying3,4; Yang, Yanqi2; Li, Xiaotong3,4; Cui, Liang3,4; Fu, Minkui3,4; Rabie, A. B.2; Zhang, Ding1
刊名EUROPEAN JOURNAL OF ORTHODONTICS
2010-12-01
DOI10.1093/ejo/cjq010
32期:6页:698-705
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者Natural Scientific Foundation of China ; Natural Scientific Foundation of Beijing ; University of Hong Kong ; Natural Scientific Foundation of China ; Natural Scientific Foundation of Beijing ; University of Hong Kong
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]OSTEOCLAST-DIFFERENTIATION ; IN-VITRO ; OSTEOBLAST DIFFERENTIATION ; RAT BONE ; OSTEOPONTIN ; CBFA1 ; OSTEOPROTEGERIN ; MODULATION ; ACTIVATOR ; MOVEMENT
英文摘要

After mechanical stress loading, CBFA1 mRNA expression was raised initially, followed by an increased expression of ALP and RANKL, decreased expression of OPG, and a change in OPN expression. After CBFA1 knock-down in human PDL cells by small hairpin (sh) RNA, the expression of ALP, OPN, OPG, and RANKL also changed. These findings suggest that in the present model system CBFA1 may play an important role in PDL-mediated bone remodelling in response to mechanical stimulation. Mechanical stress: CBFA1-ALP and OPG-PDL homeostasis may be one of the signal transduction pathways of human PDL cell differentiation under mechanical stress without exclusion of the involvement of other pathways.

语种英语
所属项目编号30340063 ; 7042034 ; 200803159006
资助者Natural Scientific Foundation of China ; Natural Scientific Foundation of Beijing ; University of Hong Kong ; Natural Scientific Foundation of China ; Natural Scientific Foundation of Beijing ; University of Hong Kong
WOS记录号WOS:000284638800019
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64134
Collection北京大学口腔医学院
作者单位1.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp Stomatol, Beijing 100871, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing 100730, Peoples R China
4.Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Yang, Ying,Yang, Yanqi,Li, Xiaotong,et al. Functional analysis of core binding factor a1 and its relationship with related genes expressed by human periodontal ligament cells exposed to mechanical stress[J]. EUROPEAN JOURNAL OF ORTHODONTICS,2010,32(6):698-705.
APA Yang, Ying.,Yang, Yanqi.,Li, Xiaotong.,Cui, Liang.,Fu, Minkui.,...&Zhang, Ding.(2010).Functional analysis of core binding factor a1 and its relationship with related genes expressed by human periodontal ligament cells exposed to mechanical stress.EUROPEAN JOURNAL OF ORTHODONTICS,32(6),698-705.
MLA Yang, Ying,et al."Functional analysis of core binding factor a1 and its relationship with related genes expressed by human periodontal ligament cells exposed to mechanical stress".EUROPEAN JOURNAL OF ORTHODONTICS 32.6(2010):698-705.
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