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学科主题: 口腔医学
题名:
Functional analysis of core binding factor a1 and its relationship with related genes expressed by human periodontal ligament cells exposed to mechanical stress
作者: Yang, Ying3,4; Yang, Yanqi2; Li, Xiaotong3,4; Cui, Liang3,4; Fu, Minkui3,4; Rabie, A. B.2; Zhang, Ding1
刊名: EUROPEAN JOURNAL OF ORTHODONTICS
发表日期: 2010-12-01
DOI: 10.1093/ejo/cjq010
卷: 32, 期:6, 页:698-705
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: OSTEOCLAST-DIFFERENTIATION ; IN-VITRO ; OSTEOBLAST DIFFERENTIATION ; RAT BONE ; OSTEOPONTIN ; CBFA1 ; OSTEOPROTEGERIN ; MODULATION ; ACTIVATOR ; MOVEMENT
英文摘要:

After mechanical stress loading, CBFA1 mRNA expression was raised initially, followed by an increased expression of ALP and RANKL, decreased expression of OPG, and a change in OPN expression. After CBFA1 knock-down in human PDL cells by small hairpin (sh) RNA, the expression of ALP, OPN, OPG, and RANKL also changed. These findings suggest that in the present model system CBFA1 may play an important role in PDL-mediated bone remodelling in response to mechanical stimulation. Mechanical stress: CBFA1-ALP and OPG-PDL homeostasis may be one of the signal transduction pathways of human PDL cell differentiation under mechanical stress without exclusion of the involvement of other pathways.

语种: 英语
所属项目编号: 30340063 ; 7042034 ; 200803159006
项目资助者: Natural Scientific Foundation of China ; Natural Scientific Foundation of Beijing ; University of Hong Kong
WOS记录号: WOS:000284638800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64134
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp Stomatol, Beijing 100871, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing 100730, Peoples R China
4.Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Yang, Ying,Yang, Yanqi,Li, Xiaotong,et al. Functional analysis of core binding factor a1 and its relationship with related genes expressed by human periodontal ligament cells exposed to mechanical stress[J]. EUROPEAN JOURNAL OF ORTHODONTICS,2010,32(6):698-705.
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