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学科主题: 药学
题名:
Chemical synthesis and calcium release activity of N-1-ether strand substituted cADPR mimic
作者: Huang, LJ; Zhao, YY; Yuan, L; Min, JM; Zhang, LH
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2002-03-25
卷: 12, 期:6, 页:887-889
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: CYCLIC-ADP-RIBOSE ; ADENOSINE 5&prime ; -DIPHOSPHATE RIBOSE ; CA2+ RELEASE ; POTENT ; ANALOGS
英文摘要:

8-Chloro cyclic inosine 5′-diphosphate ethoxymethyl ether 3 was synthesized by means of chemical method from protected inosine via phenylthio-type biphosphate substrate. The detection of Ca2+ release activity shows that 3 is a potent agonist of cADPR and has activity in intact Hela cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000175291700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64137
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Peking Univ, Hlth & Drug Analyt Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Huang, LJ,Zhao, YY,Yuan, L,et al. Chemical synthesis and calcium release activity of N-1-ether strand substituted cADPR mimic[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2002,12(6):887-889.
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