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Stem-cell therapy for erectile dysfunction
Lin, Ching-Shwun1; Xin, Zhongcheng2; Dai, Jican3; Huang, Yun-Ching4; Lue, Tom F.1
关键词clinical trial erectile dysfunction preclinical study stem-cell therapy
刊名EXPERT OPINION ON BIOLOGICAL THERAPY
2013-11-01
DOI10.1517/14712598.2013.847085
13期:11页:1585-1597
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
资助者National Institutes of Health ; National Institutes of Health
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]CAVERNOUS NERVE INJURY ; QUALITY-OF-LIFE ; STRESS URINARY-INCONTINENCE ; LOCALIZED PROSTATE-CANCER ; SECRETE CXCL5 CYTOKINE ; INDUCED DIABETIC-RATS ; PEYRONIES-DISEASE ; SMOOTH-MUSCLE ; NITRIC-OXIDE ; BONE-MARROW
英文摘要

Introduction: Stem cells (SCs) have been investigated for the treatment of erectile dysfunction (ED).

Areas covered: This review covers key disease targets and all 33 preclinical studies, including their use of SC types, animal models, transplantation routes, and outcome assessment methods.

Expert opinion: In the past one and half years there have been more stem-cell-for-erectile-dysfunction studies than the prior 8 years combined. These new studies tend to use combinatory treatment approaches by modifying or supplementing SCs with angiogenic or neurotrophic genes or proteins. However, when considering all risks and benefits, these combinatory approaches do not seem more advantageous than single-SC approaches. Another trend is the choice of transplantation routes other than the standard intracavernous (IC) injection. However, with the exception of intravenous injection, these new transplantation approaches are more cumbersome than IC injection and yet offer no evidence of producing better outcomes. In contrast to these variations, a consensus among these studies is the suggestion that paracrine action, as opposed to cellular differentiation, is the principal therapeutic mechanism. In conclusion, IC injection of a single SC type should be the choice protocol for initial clinical trials, and this is clearly the case with two clinical trials that are currently recruiting patients.

语种英语
所属项目编号DK045370
资助者National Institutes of Health ; National Institutes of Health
WOS记录号WOS:000325712100011
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64144
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Beijing 100009, Peoples R China
2.Chang Gung Mem Hosp, Div Urol, Dept Surg, Chiayi, Taiwan
3.Univ Calif San Francisco, Sch Med, Dept Urol, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
4.Jiaotong Univ, Affiliated Renji Hosp, Dept Urol, Shanghai 200001, Peoples R China
推荐引用方式
GB/T 7714
Lin, Ching-Shwun,Xin, Zhongcheng,Dai, Jican,et al. Stem-cell therapy for erectile dysfunction[J]. EXPERT OPINION ON BIOLOGICAL THERAPY,2013,13(11):1585-1597.
APA Lin, Ching-Shwun,Xin, Zhongcheng,Dai, Jican,Huang, Yun-Ching,&Lue, Tom F..(2013).Stem-cell therapy for erectile dysfunction.EXPERT OPINION ON BIOLOGICAL THERAPY,13(11),1585-1597.
MLA Lin, Ching-Shwun,et al."Stem-cell therapy for erectile dysfunction".EXPERT OPINION ON BIOLOGICAL THERAPY 13.11(2013):1585-1597.
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