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学科主题: 临床医学
题名:
Stem-cell therapy for erectile dysfunction
作者: Lin, Ching-Shwun1; Xin, Zhongcheng2; Dai, Jican3; Huang, Yun-Ching4; Lue, Tom F.1
关键词: clinical trial ; erectile dysfunction ; preclinical study ; stem-cell therapy
刊名: EXPERT OPINION ON BIOLOGICAL THERAPY
发表日期: 2013-11-01
DOI: 10.1517/14712598.2013.847085
卷: 13, 期:11, 页:1585-1597
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: CAVERNOUS NERVE INJURY ; QUALITY-OF-LIFE ; STRESS URINARY-INCONTINENCE ; LOCALIZED PROSTATE-CANCER ; SECRETE CXCL5 CYTOKINE ; INDUCED DIABETIC-RATS ; PEYRONIES-DISEASE ; SMOOTH-MUSCLE ; NITRIC-OXIDE ; BONE-MARROW
英文摘要:

Introduction: Stem cells (SCs) have been investigated for the treatment of erectile dysfunction (ED).

Areas covered: This review covers key disease targets and all 33 preclinical studies, including their use of SC types, animal models, transplantation routes, and outcome assessment methods.

Expert opinion: In the past one and half years there have been more stem-cell-for-erectile-dysfunction studies than the prior 8 years combined. These new studies tend to use combinatory treatment approaches by modifying or supplementing SCs with angiogenic or neurotrophic genes or proteins. However, when considering all risks and benefits, these combinatory approaches do not seem more advantageous than single-SC approaches. Another trend is the choice of transplantation routes other than the standard intracavernous (IC) injection. However, with the exception of intravenous injection, these new transplantation approaches are more cumbersome than IC injection and yet offer no evidence of producing better outcomes. In contrast to these variations, a consensus among these studies is the suggestion that paracrine action, as opposed to cellular differentiation, is the principal therapeutic mechanism. In conclusion, IC injection of a single SC type should be the choice protocol for initial clinical trials, and this is clearly the case with two clinical trials that are currently recruiting patients.

语种: 英语
所属项目编号: DK045370
项目资助者: National Institutes of Health
WOS记录号: WOS:000325712100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64144
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100009, Peoples R China
2.Chang Gung Mem Hosp, Div Urol, Dept Surg, Chiayi, Taiwan
3.Univ Calif San Francisco, Sch Med, Dept Urol, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
4.Jiaotong Univ, Affiliated Renji Hosp, Dept Urol, Shanghai 200001, Peoples R China

Recommended Citation:
Lin, Ching-Shwun,Xin, Zhongcheng,Dai, Jican,et al. Stem-cell therapy for erectile dysfunction[J]. EXPERT OPINION ON BIOLOGICAL THERAPY,2013,13(11):1585-1597.
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