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学科主题: 公共卫生
题名:
A pilot study on (99)mTc-3PRGD2 scintigraphy in diagnosis of brain glioma
作者: Gao Shi1; Ma Qingjie1; Cui Qu1; Liu Lin1; Zhou Xueyan1; Jia Bing2; Chen Zuowei3; Zhang Haishan1
关键词: Radioactive tracer ; Tumor ; SPECT ; CT ; Integrin
刊名: NUCLEAR SCIENCE AND TECHNIQUES
发表日期: 2013-04-20
卷: 24, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nuclear Science & Technology ; Physics, Nuclear
研究领域[WOS]: Nuclear Science & Technology ; Physics
关键词[WOS]: BREAST-CARCINOMA ; CYCLIC RGD ; INTEGRIN ; CANCER ; ANGIOGENESIS ; TUMORS ; TC-99M-NC100692 ; THERAPY
英文摘要:

The (99)mTc-3PRGD(2) targeted SPECT/CT scanning was of significance in detecting differentiated glioma. hi this work, the diagnostic value of (99)mTc-3PRGD(2) scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent. The patients first accepted X-ray imaging to localize the detecting regions before administrating with (99)mTc-3PRGD(2) at a mean radioactivity of 849+/-115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging. Tumor samples for detecting alpha v beta 3 were collected by surgical operations two weeks after the scintigraphy. The results of CT and SPECT scanning were merged and compared. The correlation between tumor occupation (TIN ratio) and alpha v beta 3 expression level were analyzed. The TIN ratios in brain glioma were proportionally correlated to alpha v beta 3 positive cell percentage (R-2=0.9253, p<0.05). This study primarily evaluated the clinical application of (99)mTc-3PRGD(2) SPECT scintigraphy on brain glioma. The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.

语种: 英语
所属项目编号: 81271606 ; 200705327 ; 201015185 ; 201201041 ; 201102154
项目资助者: National Natural Science Foundation of China ; Research Fund of Science and Technology Department of Jilin province ; Research Fund of Shenzhen Sci-tech Department of Guangdong province
WOS记录号: WOS:000328921600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64145
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Peoples Hosp Shenzhen, Dept Nucl Med, Shenzhen 518020, Peoples R China
2.Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Gao Shi,Ma Qingjie,Cui Qu,et al. A pilot study on (99)mTc-3PRGD2 scintigraphy in diagnosis of brain glioma[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(2).
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