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A pilot study on (99)mTc-3PRGD2 scintigraphy in diagnosis of brain glioma
Gao Shi1; Ma Qingjie1; Cui Qu1; Liu Lin1; Zhou Xueyan1; Jia Bing2; Chen Zuowei3; Zhang Haishan1
关键词Radioactive tracer Tumor SPECT CT Integrin
刊名NUCLEAR SCIENCE AND TECHNIQUES
2013-04-20
24期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nuclear Science & Technology ; Physics, Nuclear
研究领域[WOS]Nuclear Science & Technology ; Physics
关键词[WOS]BREAST-CARCINOMA ; CYCLIC RGD ; INTEGRIN ; CANCER ; ANGIOGENESIS ; TUMORS ; TC-99M-NC100692 ; THERAPY
英文摘要

The (99)mTc-3PRGD(2) targeted SPECT/CT scanning was of significance in detecting differentiated glioma. hi this work, the diagnostic value of (99)mTc-3PRGD(2) scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent. The patients first accepted X-ray imaging to localize the detecting regions before administrating with (99)mTc-3PRGD(2) at a mean radioactivity of 849+/-115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging. Tumor samples for detecting alpha v beta 3 were collected by surgical operations two weeks after the scintigraphy. The results of CT and SPECT scanning were merged and compared. The correlation between tumor occupation (TIN ratio) and alpha v beta 3 expression level were analyzed. The TIN ratios in brain glioma were proportionally correlated to alpha v beta 3 positive cell percentage (R-2=0.9253, p<0.05). This study primarily evaluated the clinical application of (99)mTc-3PRGD(2) SPECT scintigraphy on brain glioma. The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.

语种英语
WOS记录号WOS:000328921600007
项目编号81271606 ; 200705327 ; 201015185 ; 201201041 ; 201102154
资助机构National Natural Science Foundation of China ; Research Fund of Science and Technology Department of Jilin province ; Research Fund of Shenzhen Sci-tech Department of Guangdong province
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64145
专题北京大学医药卫生分析中心
作者单位1.Peoples Hosp Shenzhen, Dept Nucl Med, Shenzhen 518020, Peoples R China
2.Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Gao Shi,Ma Qingjie,Cui Qu,et al. A pilot study on (99)mTc-3PRGD2 scintigraphy in diagnosis of brain glioma[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(2).
APA Gao Shi.,Ma Qingjie.,Cui Qu.,Liu Lin.,Zhou Xueyan.,...&Zhang Haishan.(2013).A pilot study on (99)mTc-3PRGD2 scintigraphy in diagnosis of brain glioma.NUCLEAR SCIENCE AND TECHNIQUES,24(2).
MLA Gao Shi,et al."A pilot study on (99)mTc-3PRGD2 scintigraphy in diagnosis of brain glioma".NUCLEAR SCIENCE AND TECHNIQUES 24.2(2013).
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