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学科主题: 口腔医学
题名:
In Vitro Communities Derived from Oral and Gut Microbial Floras Inhibit the Growth of Bacteria of Foreign Origins
作者: He, Xuesong1; Tian, Yan1; Guo, Lihong2; Ano, Takashi3; Lux, Renate1; Zusman, David R.4; Shi, Wenyuan1,2
刊名: MICROBIAL ECOLOGY
发表日期: 2010-10-01
DOI: 10.1007/s00248-010-9711-9
卷: 60, 期:3, 页:665-676
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ecology ; Marine & Freshwater Biology ; Microbiology
研究领域[WOS]: Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Microbiology
关键词[WOS]: PERIODONTAL-DISEASE ; DIVERSITY ; MICE ; DNA ; MICROORGANISMS ; ENDOCARDITIS ; SUBGINGIVAL ; MICROFLORA ; RESISTANCE ; INTESTINE
英文摘要:

The gastrointestinal (GI) tract is home to trillions of microbes. Within the same GI tract, substantial differences in the bacterial species that inhabit the oral cavity and intestinal tract have been noted. While the influence of host environments and nutritional availability in shaping different microbial communities is widely accepted, we hypothesize that the existing microbial flora also plays a role in selecting the bacterial species that are being integrated into the community. In this study, we used cultivable microbial communities isolated from different parts of the GI tract of mice (oral cavity and intestines) as a model system to examine this hypothesis. Microbes from these two areas were harvested and cultured using the same nutritional conditions, which led to two distinct microbial communities, each with about 20 different species as revealed by PCR-based denaturing gradient gel electrophoresis analysis. In vitro community competition assays showed that the two microbial floras exhibited antagonistic interactions toward each other. More interestingly, all the original isolates tested and their closely related species displayed striking community preferences: They persisted when introduced into the bacterial community of the same origin, while their viable count declined more than three orders of magnitude after 4 days of coincubation with the microbial flora of foreign origin. These results suggest that an existing microbial community might impose a selective pressure on incoming foreign bacterial species independent of host selection. The observed inter-flora interactions could contribute to the protective effect of established microbial communities against the integration of foreign bacteria to maintain the stability of the existing communities.

语种: 英语
所属项目编号: GM54666
项目资助者: NIH
WOS记录号: WOS:000282971400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64147
Appears in Collections:北京大学口腔医学院_口腔生物研究室_期刊论文

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作者单位: 1.Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90095 USA
2.Peking Univ, Dept Oral Biol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Kinki Univ, Dept Biotechnol Sci, Kinokawa City, Wakayama 6496493, Japan
4.Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

Recommended Citation:
He, Xuesong,Tian, Yan,Guo, Lihong,et al. In Vitro Communities Derived from Oral and Gut Microbial Floras Inhibit the Growth of Bacteria of Foreign Origins[J]. MICROBIAL ECOLOGY,2010,60(3):665-676.
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