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学科主题临床医学
Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol
Zhang, Yong-gang; Li, Yu-guang; Liu, Bao-guo; Wei, Rui-hong; Wang, Dong-ming; Tan, Xue-rui; Bu, Ding-fang; Pang, Yong-zheng; Tang, Chao-shu
关键词cardiac remodeling cardiac fibrosis GPR14 receptor urotensin II collagen
刊名ACTA PHARMACOLOGICA SINICA
2007
DOI10.1111/j.1745-7254.2007.00485.x
28期:1页:36-43
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CONGESTIVE-HEART-FAILURE ; SMOOTH-MUSCLE-CELLS ; SPINAL-CORD ; EXPRESSION ; IMMUNOREACTIVITY ; PROLIFERATION ; FIBROBLASTS ; RECEPTORS ; DISEASE
英文摘要

Aim: To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO). Methods: Thirty male Wistar rats were randomly divided into 3 groups. Group 1 was the healthy control group, group 2 was the ISO group, and group 3 was the ISO+UII group. In groups 2 and 3, ISO (5 mg.kg(-1).d(-1)) was given (sc) once daily for 7 d. Group 3 was also given UII in the first day [3 nmol/kg (5 ug/kg), iv], followed by sc (1.5 ug/kg) twice daily. Group 1 received 0.9% saline. UII receptor (UT) mRNA expression was determined by RT-PCR. The contents of UII and angiotensin II (Ang II) were determined by radioimmunoassay. In vitro, the effects of UII on DNA/collagen synthesis of cardiac fibroblasts were determined by [H-3]thymidine/[H-3]proline incorporation. Results: The ratio of heart weight/body weight, plasma lactate dehydrogenase activity, myocardial malondialdehyde and hydroxyproline concentration increased significantly in the ISO group, as well as UT mRNA expression, plasma and cardiac UII and ventricular Ang II, compared with the control group (P < 0.01). ISO induced significant myocardial fibrogenesis. Moreover, UII+ISO co-treatment significantly increased the changes of biochemical markers of injury and the degree of cardiac hypertrophy and fibrosis. In vitro, 5x10(-9)-5x10(-7)mol/L UII stimulated [H-3]thymidine/[H-3] proline incorporation into cardiac fibroblasts in a dose-dependent manner (P < 0.01). Conclusion: These results suggest that UII was involved in the development of cardiac fibrosis and hypertrophy by synergistic effects with ISO.

语种英语
WOS记录号WOS:000243230100005
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64150
专题北京大学第一临床医学院_心血管内科
作者单位1.Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Cardiovasc Dis, Shantou 515041, Peoples R China
2.Hebei Univ Engn, Sch Med, Affiliated Hosp, Hebei 056029, Peoples R China
3.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yong-gang,Li, Yu-guang,Liu, Bao-guo,et al. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol[J]. ACTA PHARMACOLOGICA SINICA,2007,28(1):36-43.
APA Zhang, Yong-gang.,Li, Yu-guang.,Liu, Bao-guo.,Wei, Rui-hong.,Wang, Dong-ming.,...&Tang, Chao-shu.(2007).Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol.ACTA PHARMACOLOGICA SINICA,28(1),36-43.
MLA Zhang, Yong-gang,et al."Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol".ACTA PHARMACOLOGICA SINICA 28.1(2007):36-43.
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