IR@PKUHSC  > 北京大学药学院
学科主题药学
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo
Xing, Fengxia1; Li, Shenglin1; Ge, Xiyuan1; Wang, Cunyu2; Zeng, Huihui3; Li, Dong1; Dong, Ling1
关键词Thioredoxin reductase Tongue cancer Organoselenium compound BBSKE
刊名ORAL ONCOLOGY
2008-10-01
DOI10.1016/j.oraloncology.2007.12.001
44期:10页:963-969
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]THIOREDOXIN REDUCTASE INHIBITOR ; ORAL-CANCER ; ANTICANCER ACTIVITY ; GROWTH-INHIBITION ; DNA-DAMAGE ; CELL-LINES ; APOPTOSIS ; CARCINOMA ; SELENIUM ; MECHANISM
英文摘要

The aim of this study was to evaluate the anti-cancer effect of a novel organoselenium compound BBSKE (1,2-[bis(1,2-Benzisoselenazolone-3(2H)-ketone)]ethane, BBSKE, PCT: CN02/00412) on cell growth and apoptosis, focusing on the protein activity of Thioredoxin Reductase (TrxR) and Caspase-3, in oral squamous cell carcinoma (OSCC) in vitro and in vivo. Oral squamous cancer cell tine Tca8113 was treated with various concentrations of BBSKE. Growth and apoptosis as well as the protein activities were analyzed. Morphologic changes of Tca8113 cells after 24 h treatment of BBSKE were determined by fluorescence microscopy. The increase of Caspase-3 activity and decrease of Thioredoxin reductase (TrxR) activity were also measured. BBSKE induced a significant cell growth inhibition and elicited typical apoptotic morphologic changes (chromatic condensation, nucleus fragmentation). This phenomenon was accompanied by a change in protein activity of Thioredoxin reductase (TrxR) and Caspase-3. The anti-cancer effect of BBSKE was then studied in well-established Tca8113 xenografts in nude mice. In those tumors, anti-cancer effects were observed and significantly higher than the controls. Together, these results indicate that BBSKE can inhibit tongue cancer cell proliferation in vitro and in vivo, and induce apoptosis in Tca8113 cell tines partially via inhibiting the activity of TrxR and promoting the activity of Caspase-3. (C) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000261081800009
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64151
专题北京大学药学院
作者单位1.UCLA Dent, Div Oral Biol & Med, Los Angeles, CA 90095 USA
2.Peking Univ, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xing, Fengxia,Li, Shenglin,Ge, Xiyuan,et al. The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo[J]. ORAL ONCOLOGY,2008,44(10):963-969.
APA Xing, Fengxia.,Li, Shenglin.,Ge, Xiyuan.,Wang, Cunyu.,Zeng, Huihui.,...&Dong, Ling.(2008).The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.ORAL ONCOLOGY,44(10),963-969.
MLA Xing, Fengxia,et al."The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo".ORAL ONCOLOGY 44.10(2008):963-969.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xing, Fengxia]的文章
[Li, Shenglin]的文章
[Ge, Xiyuan]的文章
百度学术
百度学术中相似的文章
[Xing, Fengxia]的文章
[Li, Shenglin]的文章
[Ge, Xiyuan]的文章
必应学术
必应学术中相似的文章
[Xing, Fengxia]的文章
[Li, Shenglin]的文章
[Ge, Xiyuan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。