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学科主题: 临床医学
题名:
The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice
作者: Wiesenborn, Denise S.1; Menon, Vinal1,2; Zhi, Xu1,3; Do, Andrew1; Gesing, Adam4; Wang, Zhihui; Bartke, Andrzej5; Altomare, Deborah A.1; Masternak, Michal M.1,6
关键词: Ames dwarf ; insulin ; adipose tissue ; skeletal muscle ; adiponectin ; obesity
刊名: AGING-US
发表日期: 2014-10-01
卷: 6, 期:10, 页:900-912
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: LONG-LIVED MICE ; GROWTH-HORMONE ; GENE-EXPRESSION ; DIETARY RESTRICTION ; LIFE EXTENSION ; HUMANS ; SENSITIVITY ; ADIPONECTIN ; LONGEVITY ; RESISTANCE
英文摘要:

Long-living Ames dwarf (df/df) mice are homozygous for a mutation of the Prop1(df) gene. As a result, mice are deficient in growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). In spite of the hormonal deficiencies, df/df mice live significantly longer and healthier lives compared to their wild type siblings. We studied the effects of calorie restriction (CR) on the expression of insulin signaling genes in skeletal muscle and adipose tissue of normal and df/df mice. The analysis of genes expression showed that CR differentially affects the insulin signaling pathway in these insulin target organs. Moreover, results obtained in both normal and Ames dwarf mice indicate more direct effects of CR on insulin signaling genes in adipose tissue than in skeletal muscle. Interestingly, CR reduced the protein levels of adiponectin in the epididymal adipose tissue of normal and Ames dwarf mice, while elevating adiponectin levels in skeletal muscle and plasma of normal mice only.

In conclusion, our findings suggest that both skeletal muscle and adipose tissue are important mediators of insulin effects on longevity. Additionally, the results revealed divergent effects of CR on expression of genes in the insulin signaling pathway of normal and Ames dwarf mice.

语种: 英语
所属项目编号: R01AG032290 ; P01AG031736
项目资助者: National Institute on Aging of the National Institutes of Health
WOS记录号: WOS:000345431700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64153
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA
2.Univ S Carolina, Sch Med, Dept Cell Biol & Anat, Columbia, SC 29209 USA
3.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
4.Med Univ Lodz, Dept Oncol Endocrinol, PL-90752 Lodz, Poland
5.So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA
6.Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland

Recommended Citation:
Wiesenborn, Denise S.,Menon, Vinal,Zhi, Xu,et al. The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice[J]. AGING-US,2014,6(10):900-912.
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