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The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice
Wiesenborn, Denise S.1; Menon, Vinal1,2; Zhi, Xu1,3; Do, Andrew1; Gesing, Adam4; Wang, Zhihui; Bartke, Andrzej5; Altomare, Deborah A.1; Masternak, Michal M.1,6
关键词Ames dwarf insulin adipose tissue skeletal muscle adiponectin obesity
刊名AGING-US
2014-10-01
6期:10页:900-912
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]LONG-LIVED MICE ; GROWTH-HORMONE ; GENE-EXPRESSION ; DIETARY RESTRICTION ; LIFE EXTENSION ; HUMANS ; SENSITIVITY ; ADIPONECTIN ; LONGEVITY ; RESISTANCE
英文摘要

Long-living Ames dwarf (df/df) mice are homozygous for a mutation of the Prop1(df) gene. As a result, mice are deficient in growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). In spite of the hormonal deficiencies, df/df mice live significantly longer and healthier lives compared to their wild type siblings. We studied the effects of calorie restriction (CR) on the expression of insulin signaling genes in skeletal muscle and adipose tissue of normal and df/df mice. The analysis of genes expression showed that CR differentially affects the insulin signaling pathway in these insulin target organs. Moreover, results obtained in both normal and Ames dwarf mice indicate more direct effects of CR on insulin signaling genes in adipose tissue than in skeletal muscle. Interestingly, CR reduced the protein levels of adiponectin in the epididymal adipose tissue of normal and Ames dwarf mice, while elevating adiponectin levels in skeletal muscle and plasma of normal mice only.

In conclusion, our findings suggest that both skeletal muscle and adipose tissue are important mediators of insulin effects on longevity. Additionally, the results revealed divergent effects of CR on expression of genes in the insulin signaling pathway of normal and Ames dwarf mice.

语种英语
WOS记录号WOS:000345431700006
项目编号R01AG032290 ; P01AG031736
资助机构National Institute on Aging of the National Institutes of Health
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64153
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA
2.Univ S Carolina, Sch Med, Dept Cell Biol & Anat, Columbia, SC 29209 USA
3.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
4.Med Univ Lodz, Dept Oncol Endocrinol, PL-90752 Lodz, Poland
5.So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA
6.Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland
推荐引用方式
GB/T 7714
Wiesenborn, Denise S.,Menon, Vinal,Zhi, Xu,et al. The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice[J]. AGING-US,2014,6(10):900-912.
APA Wiesenborn, Denise S..,Menon, Vinal.,Zhi, Xu.,Do, Andrew.,Gesing, Adam.,...&Masternak, Michal M..(2014).The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice.AGING-US,6(10),900-912.
MLA Wiesenborn, Denise S.,et al."The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice".AGING-US 6.10(2014):900-912.
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