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学科主题: 临床医学
题名:
Expression of glucocorticoid receptor-alpha in the epidermis of patients with psoriasis vulgaris
作者: Pang, Xiaowen1; Zhang, Ping1; Zhu, Sainan2; Guo, Guangjin1
关键词: psoriasis vulgaris ; glucocorticoid receptor-alpha ; expression
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2015-08-01
DOI: 10.3892/etm.2015.2522
卷: 10, 期:2, 页:419-422
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CELLS
英文摘要:

Expression of glucocorticoid receptor (GR)-alpha is observed in almost all tissues and cells of the body; thus, investigating the expression of the receptor in the epidermis of patients with psoriasis vulgaris. The aim of the present study was to investigate GR-alpha expression in the epidermis of psoriasis vulgaris patients The study population consisted of 26 patients with psoriasis vulgaris and 10 normal control cases. None of the patients had received any prior treatment with glucocorticoids. Epithelial tissue samples were detected using a streptavidin peroxidation-enzymatic method for biopsy. Non-lesional tissue samples from within a range of 3 cm of lesions formed the non-lesional group, and lesional tissue samples formed the lesional group. Pathological image analysis system (named CMIAS) was used to convert image signals into numeric values, according to the optical density per unit area. GR-alpha expression was observed within the nucleus in the normal control group; however, cytoplasmic expression was observed in the lesions of the psoriatic group. The optical density values were significantly lower in the psoriatic group when compared with the normal control group, indicating a statistically significant difference in GR-alpha expression between the two groups (P<0.001), and this decreasing correlation was unaffected by the administration of steroids for 6 months. Therefore, decreased expression of GR-alpha may play an important role in the degeneration of keratinocytes in patients with psoriasis vulgaris.

语种: 英语
WOS记录号: WOS:000358679400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64156
Appears in Collections:北京大学第一临床医学院_医学统计室_期刊论文

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作者单位: 1.Peoples Liberat Army, Air Force Gen Hosp, Dept Dermatol, Beijing 100142, Peoples R China
2.Peking Univ, Hosp 1, Dept Stat, Beijing 100030, Peoples R China

Recommended Citation:
Pang, Xiaowen,Zhang, Ping,Zhu, Sainan,et al. Expression of glucocorticoid receptor-alpha in the epidermis of patients with psoriasis vulgaris[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2015,10(2):419-422.
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