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Expression of glucocorticoid receptor-alpha in the epidermis of patients with psoriasis vulgaris
Pang, Xiaowen1; Zhang, Ping1; Zhu, Sainan2; Guo, Guangjin1
关键词psoriasis vulgaris glucocorticoid receptor-alpha expression
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2015-08-01
DOI10.3892/etm.2015.2522
10期:2页:419-422
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]CELLS
英文摘要

Expression of glucocorticoid receptor (GR)-alpha is observed in almost all tissues and cells of the body; thus, investigating the expression of the receptor in the epidermis of patients with psoriasis vulgaris. The aim of the present study was to investigate GR-alpha expression in the epidermis of psoriasis vulgaris patients The study population consisted of 26 patients with psoriasis vulgaris and 10 normal control cases. None of the patients had received any prior treatment with glucocorticoids. Epithelial tissue samples were detected using a streptavidin peroxidation-enzymatic method for biopsy. Non-lesional tissue samples from within a range of 3 cm of lesions formed the non-lesional group, and lesional tissue samples formed the lesional group. Pathological image analysis system (named CMIAS) was used to convert image signals into numeric values, according to the optical density per unit area. GR-alpha expression was observed within the nucleus in the normal control group; however, cytoplasmic expression was observed in the lesions of the psoriatic group. The optical density values were significantly lower in the psoriatic group when compared with the normal control group, indicating a statistically significant difference in GR-alpha expression between the two groups (P<0.001), and this decreasing correlation was unaffected by the administration of steroids for 6 months. Therefore, decreased expression of GR-alpha may play an important role in the degeneration of keratinocytes in patients with psoriasis vulgaris.

语种英语
WOS记录号WOS:000358679400005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64156
专题北京大学第一临床医学院_医学统计室
作者单位1.Peoples Liberat Army, Air Force Gen Hosp, Dept Dermatol, Beijing 100142, Peoples R China
2.Peking Univ, Hosp 1, Dept Stat, Beijing 100030, Peoples R China
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GB/T 7714
Pang, Xiaowen,Zhang, Ping,Zhu, Sainan,et al. Expression of glucocorticoid receptor-alpha in the epidermis of patients with psoriasis vulgaris[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2015,10(2):419-422.
APA Pang, Xiaowen,Zhang, Ping,Zhu, Sainan,&Guo, Guangjin.(2015).Expression of glucocorticoid receptor-alpha in the epidermis of patients with psoriasis vulgaris.EXPERIMENTAL AND THERAPEUTIC MEDICINE,10(2),419-422.
MLA Pang, Xiaowen,et al."Expression of glucocorticoid receptor-alpha in the epidermis of patients with psoriasis vulgaris".EXPERIMENTAL AND THERAPEUTIC MEDICINE 10.2(2015):419-422.
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