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学科主题: 基础医学
题名:
Elevated levels of serum antibodies against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus
作者: Dai, H.1,2; Li, Z.3; Zhang, Y.1; Lv, P.1; Gao, X. M.1,2
关键词: alpha-1,3-mannan ; autoantibody ; autoimmune diseases ; SLE
刊名: LUPUS
发表日期: 2009-10-01
DOI: 10.1177/0961203309105131
卷: 18, 期:12, 页:1087-1090
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; INFLAMMATORY-BOWEL-DISEASE ; ANKYLOSING-SPONDYLITIS ; CELIAC-DISEASE ; ARTHRITIS
英文摘要:

This study was undertaken to investigate whether levels of anti-Saccharomyces cerevisiae mannan antibodies (ASCMAs), a serological marker for Crohn′s disease, seronegative spondyloarthritis and Behcet′s disease, also correlate with systemic lupus erythematosus (SLE) in humans. Serum samples from healthy volunteers (n = 152) and patients with SLE (n = 40) were compared for ASCMA-IgA,-IgG and -IgM levels using enzyme linked immunosorbent assays. ASCMA-IgG, but not IgM and IgA, prevalence was significantly raised in active SLE patients (57.5%) compared with healthy controls (8.5%). ASCMA-IgG levels in SLE patients during remission were relatively lower, indicating a possible correlation with disease activity. These results differ from a previous study, which did not detect a difference between ASCMA levels in SLE patients and healthy control. It remains to be evaluated whether elevated ASCMA-levels are common to all rheumatic disorders. Lupus (2009) 18, 1087-1090.

语种: 英语
所属项目编号: 2007CB512406 ; 2006AA02Z495 ; 30371303 ; 31890142
项目资助者: National Key Basic Research Programs ; &prime ; 863&prime ; Program ; Natural Science Foundation of China
WOS记录号: WOS:000269864000010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64158
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Minist Publ Hlth, Key Lab Immunol, Beijing, Peoples R China
3.Peking Univ, Dept Rheumatol, Peoples Hosp, Beijing 100191, Peoples R China

Recommended Citation:
Dai, H.,Li, Z.,Zhang, Y.,et al. Elevated levels of serum antibodies against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus[J]. LUPUS,2009,18(12):1087-1090.
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