IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Association of G72/G30 polymorphisms with early-onset and male schizophrenia
Yue, Weihua; Liu, Zhonghua; Kang, Guolian; Yan, Jun; Tang, Fulei; Ruan, Yan; Zhang, Jifeng; Zhang, Dai
关键词age at onset association study G72/G30 polymorphism schizophrenia
刊名NEUROREPORT
2006-12-18
17期:18页:1899-1902
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]BIPOLAR-AFFECTIVE-DISORDER ; AMINO-ACID OXIDASE ; INDEPENDENT SAMPLE ; GENE-EXPRESSION ; LOCUS ; HAPLOTYPE ; LINKAGE ; DISEQUILIBRIUM ; METAANALYSIS ; POPULATION
英文摘要

To explore the effect of G72/G30 polymorphisms on the clinical manifestations of schizophrenia, especially on the age at onset and sex of patients, we examined three single nucleotide polymorphisms in 216 schizophrenic patients and 321 healthy controls. Significant associations of schizophrenia with the A allele of rs947267 (P = 0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P = 0.008) were found in early-onset schizophrenic patients. So did the same allele (P = 0.034) and haplotype (P = 0.009) as mentioned above in male patients. These findings suggest that the G72/G30 gene may modulate the age at onset and there might be a potential interaction between this locus and sex in the pathogenesis of schizophrenia.

语种英语
WOS记录号WOS:000243538600013
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64159
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
3.Michigan State Univ, Dept Stat & Probabil, E Lansing, MI 48824 USA
推荐引用方式
GB/T 7714
Yue, Weihua,Liu, Zhonghua,Kang, Guolian,et al. Association of G72/G30 polymorphisms with early-onset and male schizophrenia[J]. NEUROREPORT,2006,17(18):1899-1902.
APA Yue, Weihua.,Liu, Zhonghua.,Kang, Guolian.,Yan, Jun.,Tang, Fulei.,...&Zhang, Dai.(2006).Association of G72/G30 polymorphisms with early-onset and male schizophrenia.NEUROREPORT,17(18),1899-1902.
MLA Yue, Weihua,et al."Association of G72/G30 polymorphisms with early-onset and male schizophrenia".NEUROREPORT 17.18(2006):1899-1902.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yue, Weihua]的文章
[Liu, Zhonghua]的文章
[Kang, Guolian]的文章
百度学术
百度学术中相似的文章
[Yue, Weihua]的文章
[Liu, Zhonghua]的文章
[Kang, Guolian]的文章
必应学术
必应学术中相似的文章
[Yue, Weihua]的文章
[Liu, Zhonghua]的文章
[Kang, Guolian]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。